Publications by authors named "Daniela Raguer Valadao de Souza"
Article Synopsis
- Small RNAs (sRNAs) play a significant role in regulating biological processes linked to leukemia development, especially in adult T-cell leukemia/lymphoma (ATLL) related to HTLV-1.
- The study focuses on the sRNA profile of a 30-year-old woman diagnosed with ATLL, analyzing changes before and after maintenance therapy.
- The goal is to understand how the levels of sRNA expression correlate with the patient’s response to the treatment.
Article Synopsis
- HAM/TSP is a serious illness that affects the spinal cord and currently has no good treatments.
- Scientists are looking for specific indicators, called biomarkers, to help understand and predict the disease better.
- This study found some important small RNA molecules that may help in identifying HAM/TSP and understanding how it works in the body.
The historical and social vulnerability of quilombola communities in Brazil can make them especially fragile in the face of COVID-19, considering that several individuals have precarious health systems and inadequate access to water. This work aimed to characterize the frequency of SARS-COV-2 infections and the presence of IgM and IgG SARS-CoV-2 antibodies in quilombola populations and their relationship with the presence of risk factors or preexisting chronic diseases in the quilombola communities. We analyzed the sociodemographic and clinical characteristics, serological status, comorbidities, and symptoms of 1,994 individuals (478 males and 1,536 females) from 18 Brazilian municipalities in the State of Sergipe of quilombola communities, which were evaluated at different epidemiological weeks, starting at the 32nd (August 6th) and ending at the 40th (October 3rd) epidemiological week.
View Article and Find Full Text PDFEven with the current advances that have been made in regard to COVID-19, such as a better understanding of the disease and the steady growth in the number of vaccinated individuals, it remains a challenge for humanity. Dealing with the disease in prison settings has been particularly difficult. This study sought to discover whether in-person visiting affected the number of cases of SARS-CoV-2 infection in the penitentiaries in the state of Sergipe (Brazil).
View Article and Find Full Text PDFBackground: COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health threat and remains a challenge for modern medicine. Rapid and accurate diagnosis of COVID-19 is vital for proper disease and outbreak management. Our review aimed to analyze scientific articles published in the literature addressing the rapid tests available for COVID-19 diagnosis at the first year of the pandemic.
View Article and Find Full Text PDFArticle Synopsis
- Adult T cell lymphoma/leukemia (ATLL) is caused by the HTLV-1 virus and involves changes in small RNA molecules, particularly microRNAs (miRNAs), which could serve as therapeutic targets.
- Researchers conducted small RNA sequencing on blood samples from ATLL patients, asymptomatic carriers, and healthy controls to identify sRNA expression patterns linked to the disease.
- The study found specific sRNA signatures that affect key pathways in ATLL, with miR-451-3p being notably downregulated in active patients, suggesting that these sRNAs could be useful as biomarkers for tracking disease activity.
Seroprevalence of SARS-CoV-2 IgM and IgG antibodies in an asymptomatic population in Sergipe, Brazil.
Rev Panam Salud Publica
October 2020
Objective: To estimate the prevalence of SARS-CoV-2 antibodies in an asymptomatic population in the state of Sergipe, Brazil.
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Methods: This cross-sectional study with stratified sampling (sex and age) included serological immunofluorescent tests for IgM and IgG on samples from 3 046 asymptomatic individuals.
In the present pilot study, massively parallel sequencing (MPS) technology was used to investigate cellular small RNA (sRNA) levels in the peripheral blood mononuclear cells (PBMCs) of human T-lymphotropic virus type I (HTLV-I) infected asymptomatic carriers with monoclonal (ASM) and polyclonal (ASP) T cell receptor (TCR) γ gene. Blood samples from 15 HTLV-I asymptomatic carriers (seven ASM and eight ASP) were tested for the clonal TCR-γ gene and submitted for sRNA library construction together with blood samples of five healthy controls (HCs) using Illumina sequencing platform. The sRNA-sequencing reads were aligned, annotated and profiled using various bioinformatics tools.
View Article and Find Full Text PDFThis article describes the data on the global expression profile of small RNA (smRNAs) molecules in mice gastrocnemius muscle exposed to jararhagin, snake venom metalloproteinase. The data include smRNAs in mice gastrocnemius muscle challenged with Jararhagin (Jar; =4) in the right paw or phosphate-buffered saline (PBS; control; =4) in the left paw. smRNA-Seq libraries were generated after 24 h of exposure to PBS or jararhagin.
View Article and Find Full Text PDFBackground: The aims of this study were to define the mRNA expression profiles of MYCN, DDX1, TrkA, and TrkC in biopsy tumor samples from 64 Brazilian patients with neuroblastomas of different risk stages and to correlate altered expression with prognostic values.
Procedure: Patients were retrospectively classified into low- (n = 11), intermediate- (n = 18), and high-risk (n = 35) groups using standard criteria. The mRNA levels of the above genes were measured by quantitative real-time polymerase chain reaction.