Publications by authors named "Daniela R Wozeak"
Article Synopsis
- - The study investigates antibiotic resistance and biofilm formation in Klebsiella pneumoniae strains from a university hospital in Pelotas, Brazil, highlighting the strains' persistence in hospital settings.
- - Out of 28 K. pneumoniae isolates, a significant majority (96.42%) strongly formed biofilms, with 64.29% classified as multidrug-resistant (MDR), revealing a concerning level of antibiotic resistance.
- - Genetic analysis showed 18 unique clones, indicating that the same strains circulated in different samples over two years, underscoring the need for improved control measures and disinfection protocols in hospital environments.
Aims: Currently, immunoinformatic approaches have shown promise in rapidly and cost-effectively identifying new antigens from the Leptospira proteome. Chimeric multiepitope proteins offer a strategy with significant potential for implementation in diagnosis and vaccines development.
Methods And Results: In this study, we detail the immunoinformatic analyses and design of a new recombinant chimeric protein constructed with epitopes identified from the sequences of ErpY-like and LemA proteins, previously identified as potential antigens for controlling leptospirosis.
Acinetobacter baumannii is an opportunistic bacterium that causes infection in several sites. Carbapenem-resistant A. baumannii strains (CRAb) lead the World Health Organization's list of 12 pathogens considered a priority for developing new antimicrobials.
View Article and Find Full Text PDFA significant cause of mortality in the intensive care unit (ICU) is multidrug-resistant (MDR) Gram-negative bacteria, such as carbapenemase (KPC). Biofilm production is a key factor in KPC colonization and persistence in the host, making the treatment difficult. The aim of this study was to evaluate the antibiotic resistance, molecular and phenotypic biofilm profiles of 12 KPC isolates associated with nosocomial infection in a hospital in Pelotas, Rio Grande do Sul, Brazil.
View Article and Find Full Text PDFThe increase in multidrug-resistant (MDR) Acinetobacter baumannii strains in hospital environments has generated great concern around the world. Biofilm is one of the forms of bacterial adaptation that is increasingly leading to antimicrobial resistance and therapeutic failure. The search for alternative therapeutic strategies, especially non-antibiotic-based, is urgently needed.
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