Persistent serovar Typhimurium Infection Increases the Susceptibility of Mice to Develop Intestinal Inflammation.

Chronic intestinal inflammations are triggered by genetic and environmental components. However, it remains unclear how specific changes in the microbiota, host immunity, or pathogen exposure could promote the onset and exacerbation of these diseases. Here, we evaluated whether serovar Typhimurium (.

Interleukin-10 Production by T and B Cells Is a Key Factor to Promote Systemic Serovar Typhimurium Infection in Mice.

serovar Typhimurium (. Typhimurium) is a Gram-negative bacterium that produces disease in numerous hosts. In mice, oral inoculation is followed by intestinal colonization and subsequent systemic dissemination, which leads to severe pathogenesis without the activation of an efficient anti- immune response.

Role of Salmonella enterica exposure in Chilean Crohn's disease patients.

Aim: To study the association between exposure to Salmonella enterica (SE) and Crohn's disease (CD) and its clinical implications in Chilean patients.

Methods: Ninety-four unrelated Chilean CD patients from CAREI (Active Cohort Registry of Inflammatory Bowel Disease) presenting to a single inflammatory bowel disease (IBD) unit of a University Hospital were prospectively included in this study. A complete clinical evaluation, including smoking history, was performed at the initial visit, and all the important data of clinical evolution of CD were obtained.