Publications by authors named "Daniela Nogara"
Aim: To evaluate the effect of metformin on cancer incidence in subjects with overweight/obesity and/or prediabetes/diabetes.
Materials And Methods: We searched MEDLINE, Embase and CENTRAL for randomized controlled trials (RCTs) in adults with overweight/obesity and/or prediabetes/diabetes that compared metformin to other interventions for ≥24 weeks. Independent reviewers selected and extracted data including population and intervention characteristics and new diagnoses of cancer.
Article Synopsis
- Acute liver failure (ALF) leads to rapid liver dysfunction, causing issues like hepatic encephalopathy (HE), which is influenced by brain changes such as astrocyte dysfunction and energy metabolism problems.
- A study on rats showed that those with ALF had higher ammonia and lactate levels and exhibited significant signs of astrocytic reactivity and alterations in brain energy metabolism.
- Findings indicated that early-stage ALF results in a hypermetabolic brain state, increased oxidative stress, and heightened astrocytic activity, partly due to elevated mitochondrial oxidation of glutamate.
Background: Dietary interventions have limited success in promoting sustainable weight loss; new treatments allowing better compliance with hypocaloric diets should be developed. The aim of this trial is to describe the effects of a protocol combining repetitive active transcranial direct current stimulation (tDCS) with a hypocaloric diet on weight loss and food consumption in overweight or obese adults.
Methods/design: Overweight or obese adults between 20 and 50 years of age with stable weight over the last 4 months will be selected for a 4-week randomized clinical trial of fixed-dose tDCS (20 sessions; 5 consecutive weekdays/wk, 2 mA, 20 minutes) over the right dorsolateral prefrontal cortex associated with a weight loss diet.