Publications by authors named "Daniela Maiz"
Article Synopsis
- High grade serous ovarian cancer (HGSOC) is a deadly gynecologic cancer that shows limited response to existing immunotherapies, highlighting the need for new immune targets, particularly focusing on the role of mast cells which increase after chemotherapy treatment.
- The study utilized immunohistochemistry methods to analyze mast cell levels in 36 HGSOC patient tumors before and after neoadjuvant chemotherapy (NACT), revealing significant changes in mast cell populations and their association with clinical outcomes.
- Results indicated that higher mast cell levels post-NACT were linked to poorer patient survival outcomes, with specific forms of mast cells (Tryptase+/CPA3+) showing a strong correlation with overall survival rates.
Selection of an Efficient AAV Vector for Robust CNS Transgene Expression.
Mol Ther Methods Clin Dev
December 2019
Adeno-associated virus (AAV) capsid libraries have generated improved transgene delivery vectors. We designed an AAV library construct, iTransduce, that combines a peptide library on the AAV9 capsid with a Cre cassette to enable sensitive detection of transgene expression. After only two selection rounds of the library delivered intravenously in transgenic mice carrying a Cre-inducible fluorescent protein, we flow sorted fluorescent cells from brain, and DNA sequencing revealed two dominant capsids.
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