Publications by authors named "Daniela I Cacciabue"
Article Synopsis
- Traditional methods for accessing the human cochlear nerve are limited due to its location within the skull's bony structure.
- This study introduces a minimally invasive technique for directly reaching the cochlear nerve to apply new regenerative treatments.
- Using advanced imaging and anatomical studies, researchers identified a safe pathway to the nerve and successfully validated it on multiple human temporal bones.
The human inner ear contains minute three-dimensional neurosensory structures that are deeply embedded within the skull base, rendering them relatively inaccessible to regenerative therapies for hearing loss. Here we provide a detailed characterisation of the functional architecture of the space that hosts the cell bodies of the auditory nerve to make them safely accessible for the first time for therapeutic intervention. We used synchrotron phase-contrast imaging which offers the required microscopic soft-tissue contrast definition while simultaneously displaying precise bony anatomic detail.
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