Publications by authors named "Daniela Hacker"
Article Synopsis
- AcD neurons have a unique structure where the axon comes from a basal dendrite instead of the cell body, allowing for specific action potential generation in the axon initial segment (AIS).
- Research shows that this AcD morphology develops independently of synaptic connections and the surrounding environment, starting from a single precursor neurite.
- Although the AIS in AcD neurons has a similar structure and functions like that from other neurons, it displays differences in plasticity, organelle presence, and inhibitory input, highlighting the importance of axon origin in neuron function.
The vast majority of excitatory synapses are formed on small dendritic protrusions termed dendritic spines. Dendritic spines vary in size and density that are crucial determinants of excitatory synaptic transmission. Aberrations in spine morphogenesis can compromise brain function and have been associated with neuropsychiatric disorders.
View Article and Find Full Text PDFSynaptic vesicle (SV) release probability (Pr), determines the steady state and plastic control of neurotransmitter release. However, how diversity in SV composition arises and regulates the Pr of individual SVs is not understood. We found that modulation of the copy number of the noncanonical vesicular SNARE (soluble -ethylmaleimide-sensitive factor attachment protein receptor), vesicle-associated membrane protein 4 (VAMP4), on SVs is key for regulating Pr.
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