Publications by authors named "Daniela Gottfried"
Cells expressing the cytokine-inducible NO synthase are known to trigger apoptosis in neighboring cells. Paramagnetic dinitrosyl nonheme iron complexes (DNIC) were found in tumor tissue about 40 years ago; however, the role of these NO(+)-bearing species is not completely understood. In the human Jurkat leukemia cell line, the application of the model complex DNIC-thiosulfate (50-200 microM) induced apoptosis (defined by phosphatidylserine externalization) in a concentration- and time-dependent manner.
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- Some tumors make a substance called inducible NO synthetase (NOS2), but we don't fully understand how it affects tumor growth.* -
- We found that short bursts of this NO can help cells die when they should, but over time, some cells become resistant to dying and can survive even when attacked by the immune system.* -
- In the beginning, NO might help get rid of bad cells, but if it doesn't work, it helps cancer cells become tougher and avoid being destroyed by the body's defenses.*
The ability of tumour cells to resist apoptosis-inducing signals by cytotoxic T cells may decide the success or failure of tumour elimination. An important effector of apoptosis is the CD95/CD95 ligand system (APO-1/Fas) that mediates perforin-independent cytotoxic T-cell killing of tumour cells. We propose a new strategy by which tumour cells can resist CD95-induced apoptosis.
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