Publications by authors named "Daniela Garcia-Castillo"
The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes and relocalization of the Golgi SNARE protein syntaxin-5 to the endoplasmic reticulum. The molecular mechanisms by which this is achieved remain unknown.
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- Rab6 is a highly conserved and abundant protein involved in various transport processes at the Golgi complex, generated from two isoforms, Rab6A and Rab6A', through alternative splicing.
- Mice lacking the RAB6A gene died early in development, while studies on mouse embryonic fibroblasts (MEFs) revealed that Rab6 depletion disrupts cell growth, alters Golgi structure, and reduces the levels of known effectors.
- The study concludes that RAB6 is essential for embryonic development and confirms its critical functions in MEFs, showcasing its role in protecting against toxins and regulating transport.
Cyclic AMP suppresses immune cell activation and inflammation. The positive feedback loop of proinflammatory cytokine production and immune activation implies that cytokines may not only be regulated by cyclic AMP but also conversely regulate cyclic AMP. This study examined the effects of tumor necrosis factor (TNF)-α and interleukin (IL)-1β on cyclic AMP-phosphodiesterase (PDE) signaling in microglia in vitro and after spinal cord injury (SCI) or traumatic brain injury (TBI).
View Article and Find Full Text PDFDespite a growing number of U.S. citizens who do not speak English fluently, little literature attends to issues of accurate translation of medical documents.
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