Publications by authors named "Daniela F Cardus"
Article Synopsis
- miR-506-3p is a powerful factor in promoting neuroblastoma cell differentiation, suggesting it could be a valuable tool for differentiation therapy in this cancer type.
- The study used gene expression profiling and high-content screening to find target genes of miR-506-3p, identifying 19 genes that affect cell differentiation, with 13 of them linked to poorer patient survival.
- The research highlights new target genes that could help us understand how miR-506-3p influences neuroblastoma cell differentiation, potentially leading to new therapies that target these pathways.
Article Synopsis
- Researchers performed a high-content screening in neuroblastoma cells to find cell cycle regulators affecting cell differentiation, discovering that knocking down CDKN3 induced significant neurite outgrowth and differentiation markers.
- CDKN3 knockdown led to decreased proliferation markers and reduced colony formation in neuroblastoma cells, correlating high CDKN3 levels with poor patient survival in public datasets.
- The study also revealed that differentiation molecules down-regulate CDKN3, while N-Myc promotes its expression, suggesting a complex regulatory network that plays a role in neuroblastoma progression.
microRNA mimics are synthetic RNA molecules that imitate the mature miRNA duplexes and their functions. These mimics have shown promise in treating cancers. Nucleotide chemical modifications of microRNA mimics have been investigated and have improved the stability of miRNA mimics.
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