Publications by authors named "Daniela Duenas"
Article Synopsis
- The study followed patients with early-stage follicular lymphoma (ESFL) who were treated with involved field radiotherapy (IFRT) alone or combined with chemotherapy (cyclophosphamide/vincristine/prednisolone) and later added rituximab to the treatment, analyzing its effects over an 11.3-year period.* -
- Results showed that those receiving IFRT plus rituximab (IFRT + R-CVP) had significantly better progression-free survival rates (62% vs. 43%) compared to IFRT alone, even though overall survival rates didn’t differ significantly.* -
- Additionally, higher expression of the CD8A gene in biopsy samples was associated with improved outcomes, suggesting that immune
Adult T-cell leukemia-lymphoma (ATLL) is an aggressive malignancy driven by human T-cell leukemia virus type 1 (HTLV-1). Although patients from the Western hemisphere (Afro-Caribbean and South American) face worse prognoses, our understanding of ATLL molecular drivers derives mostly from Japanese studies. We performed multi-omic analyses to elucidate the genomic landscape of ATLL in Western cohorts.
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- Acute myeloid leukemia (AML) is the most prevalent type of acute leukemia in adults, but many patients relapse after initial chemotherapy, highlighting the need for new treatments.
- CD70 is identified as a potential therapeutic target, as it interacts with CD27 and may help improve remission rates in relapsed AML.
- The study utilized diagnostic techniques like immunohistochemistry and flow cytometry to assess CD70 expression in bone marrow samples from both untreated and relapsed AML patients, exploring the effects of hypomethylating agents on this expression.
Unlabelled: Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive, rare lymphoma of natural killer (NK) cell origin with poor clinical outcomes. Here we used phenotypic and molecular profiling, including epigenetic analyses, to investigate how ENKTL ontogeny relates to normal NK-cell development. We demonstrate that neoplastic NK cells are stably, but reversibly, arrested at earlier stages of NK-cell maturation.
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- Plekha7 is a protein that helps cells stick together and keep strong barriers, which is important for cell health, especially in the lining of the intestines.
- In colorectal cancer, levels of Plekha7 are higher than normal and increase as the cancer gets worse.
- Plekha7 works better with normal KRas proteins than with mutated ones, and stopping Plekha7 can slow down the growth of tumors caused by mutated KRas.
Extranodal NK/T-cell lymphoma (ENKTL) is an Epstein-Barr virus (EBV) associated lymphoma, prevalent in Asia and Latin America. Studies in Asian cohorts have identified some recurrent gene mutations in ENKTL; however, the mutational landscape of ENKTL in Latin America is unknown. In this study, we investigated the mutational profile and EBV strains of 71 ENKTL cases from Latin America (42 from Mexico, 17 from Peru, and 12 from Argentina) and compared it with Asian cohorts.
View Article and Find Full Text PDFUndifferentiated (embryonal) liver sarcoma is a rare tumor about 2% of all malignant liver tumors with a poor prognosis and usually occurs in children, this review aims to assess cases of primary embryonal sarcoma of the liver presented at our institution the past 8 years and improve recognition of its variants and evaluate immunohistochemical characteristics that help differentiated it from other tumors. Six cases of undifferentiated liver sarcoma were histologically evaluated and investigated by immunohistochemistry with a panel of antibodies using the equipment “Autostainer Link 48â€. Usually masses were on average more than 20 cm, with solid, cystic, mucinous areas.
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