Publications by authors named "Daniela Boisteanu"

Coronary artery anomalies (CAAs) represent a group of rare cardiac abnormalities with an incidence of up to 1.2%. The aim of this retrospective study was to conduct a comprehensive epidemiological assessment of the prevalence of hypoplastic coronary arteries using coronary computed tomography angiography (CCTA) in patients with diagnosed CAAs and individuals presenting with cardiovascular manifestations in the north-eastern region of Romania.

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Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse, chronic hypoxia and a proinflammatory phenotype. The purpose of our study was to evaluate readily available inflammatory biomarkers (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), WBC-to-MPV ratio (WMR) and lymphocyte-to-C-reactive protein ratio (LCR)) before and after CPAP in patients with moderate-severe OSA. We performed a prospective study that included patients with newly-diagnosed moderate-severe OSA.

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Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive airway therapy (CPAP) in reversing this detrimental vascular remodeling. Arterial stiffness is increasingly acknowledged as a major cardiovascular risk factor and a marker of subclinical hypertension-mediated organ damage.

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Obstructive sleep apnea (OSA) is the most common form of sleep-disordered breathing, exhibiting an increasing prevalence and several cardiovascular complications. Continuous positive airway pressure (CPAP) is the gold-standard treatment for moderate-severe OSA, but it is associated with poor patient adherence. We performed a prospective study that included 57 patients with newly diagnosed moderate-severe OSA, prior to CPAP initiation.

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The aim of this study was to assess the influence of obstructive sleep apnea syndrome (OSAS) on the change in anthropometric parameters and body composition, in patients undergoing laparoscopic sleeve gastrectomy (LSG). This prospective study included patients undergoing LSG who had pre-operative polysomnography data and were also evaluated at six and 12 months after surgery. All patients included also had whole body composition analysis data before surgery and at six and 12 months after surgery.

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Obstructive sleep apnea (OSA) is associated with daytime somnolence, cognitive impairment and high cardiovascular morbidity and mortality. Obesity, associated cardiovascular comorbidities, accelerated erythropoiesis and muscular mitochondrial energetic dysfunctions negatively influence exercise tolerance in moderate-severe OSA patients. The cardiopulmonary exercise testing (CPET) offers an integrated assessment of the individual's aerobic capacity and helps distinguish the main causes of exercise limitation.

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Article Synopsis
  • - Obstructive sleep apnea (OSA) leads to recurrent breathing interruptions, increasing stress on the cardiovascular system and affecting heart function, particularly in moderate to severe cases.
  • - Advanced imaging techniques like three-dimensional echocardiography and two-dimensional speckle tracking are crucial for assessing heart function and detecting early signs of myocardial dysfunction in OSA patients.
  • - Early identification of subtle heart changes in OSA patients through thorough echocardiographic assessments could improve treatment adherence and health outcomes, necessitating further research in this area.
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Introduction: In non-exacerbation chronic obstructive pulmonary disease (COPD) with mild lung function impairment, single bronchodilator therapy might be as effective as combined inhaled corticosteroid/bronchodilator therapy, whereas the risk of pneumonia associated with the latter would be practically absent.

Areas Covered: We performed an analysis of a recent study evaluating the efficacy and safety of inhaled indacaterol versus inhaled salmeterol/fluticasone in COPD patients.

Expert Opinion: Both therapies were found to exert comparable effects on lung function, symptom severity and health status.

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Article Synopsis
  • - The study assessed socio-demographic and lifestyle factors among 254 participants to determine their association with obstructive sleep apnea syndrome (OSAS) risk, finding that age, occupation, and physical activity play significant roles.
  • - High risk for OSAS was notably higher in older adults (especially retirees) and women, with 29.4% of men and 36.8% of women classified as high risk; factors like smoking and alcohol consumption did not show significant impacts.
  • - Interestingly, participants with a low risk for OSAS tended to engage in more physical activity at work and performed significantly more vigorous exercise, suggesting a link between physical fitness and lower OSAS risk.
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Aim: Obstructive Sleep Apnea Syndrome (OSAS) is an under diagnosed condition with significant consequences on health. The aim of this study is to estimate the prevalence of symptoms and key features of OSAS in a rural population.

Material And Methods: 254 subjects were enrolled.

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Unlabelled: It is generally considered that obstructive sleep apnea may associate larynx abnormalities--either anatomic or functional in nature; considering the vocal tract as a series of uniform loss cylindrical pipes the idea of non-invasively exploring this by means of spectral analysis emerged. The aim of our study is to evaluate potential changes in acoustic features of voice in sleep apnea patients as compared to matched controls in order to develop a potential screening test.

Material And Method: Sleep apnea subjects and controls were asked to produce sustained vowels such as "a" and "i" which were recorded and analyzed.

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The MDR character is a major factor that influence the effectiveness of cancer chemotherapy. This feature can be noninvasively evaluated through 99mTc isonitrils (MIBI, Tetrofosmin) scintigraphy, because these radiotracers cellular efflux is mediated by the Pgp membranar active transport system, the same that mediate chemotherapy drugs cellular efflux. The Pgp glycoprotein overexpression in the case of the MDR positive tumoral cells will determine both the chemotherapic drug and the isonitrile radiotracer quickly efflux from the cell.

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Unlabelled: Obstructive sleep (OSA) can induce severe arrhythmias, including prolonged periods of asystole and heart block. Heart rate variability (HRV) has gained importance as a technique employed to explore the autonomic nervous system (ANS) which plays an important role in arrythmogenesis.

Aims: Our aim was to investigate nocturnal HRV by spectral analysis of RR intervals before and after continuous positive airway pressure (nCPAP) therapy.

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The prevalence of sleep disorders is significantly higher (up to 80%) in patients with chronic uremia compared to the general population. Sleep disorders appear even in the early stages of chronic kidney disease. These disturbances are complex, including difficulties in falling asleep and awakening, interrupted sleep, nightmares, restless legs syndrome, sleep apnea syndrome, etc.

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The classic concept of the renin-angiotensin system being substantially accomplished by the new cognitive and applicative acquisitions, a natural reconsideration and completion is imposed. In consequence, ample referrals are made to the main central and peripheral actions of Angiotensins through specific receptors. Emphasis is given to the effects of Angiotensin IV and Angiotensin 1-7 which are different of those of Angiotensin II, underlining their possible role as counteracting factors to its actions, in order to remove the imbalances created by the predominating stimulation of vasoconstricting AT, receptors.

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LAM, a rare lung disease typically affecting women of reproductive age, is characterized by abnormal proliferation of smooth--muscle cells and progressive loss of pulmonary function due to destruction of lung parenchyma. Two cases of bilateral successive recurrent spontaneous pneumothorax and haemoptysis are presented. Repeated conventional and video-assisted surgery was required in both cases, for drainage of the recurrent pneumothorax and resection of subpleural bulla, with good immediate postoperative evolution.

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Unlabelled: The aim of our study was to compare the role of lung perfusion scintigraphy with 1mTc MIBI and 99mTc Tetrofosmin (Mw) for the initial diagnostic evaluation of pulmonary tuberculosis-PTB).

Material And Method: Two groups of new PTB diagnosed patients, without treatment, were studied: group I--41 patients were imaged with 99mTc MIBI (sex ratio men:women = 17:24, mean age 25 years, 26 positive Mycobacterium Tuberculosis (MT) smears, 15 negative MT smears), group II--40 patients were imaged with 99mTc Mw (sex ratio men:women = 21:19; mean age: 32.5 years; 31 positive MT smears, 9 negative MT smears.

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Adrenomedullin (ADM), a ubiquitous vasoactive peptide, has been the target of a multitude of studies concerning its effect on the vascular tone. The present work aims at clarifying a series of its interactions with the renin-angiotensin system. The study uses the rat aorta ring as a model of conductance vessels, with or without vascular endothelium, and the second order branch of rat mesenteric arteries as a model of resistance arteries.

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After a brief presentation of the immune system as sensorial and effector organ, which recognizes and defends against cellular aggressions, the main psychoneuroendocrine components of immune reaction regulation and modulation are shown. Both central nervous structures that control the hormonal emissions, the vegetative innervation of the lymphoid organs as wells as the afferent neurohumoral pathways involved in the making of the self-regulating and neuromodulating circuits of the humoral and cellular immune responses are mentioned. An important position is held by the interrelations between the hypothalamus-pituitary-corticoadrenal gland, the sympathetic-parasympathetic efferent pathways and the chemical messengers (hormones, neurotransmitters, interleukins, neurotrophins) which make possible the bi-directional neuroimmune communication for maintaining the homeostatic balances on this third effector pathway, too.

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After a brief presentation of the immune system as sensorial and effector organ, which recognizes and defends against cellular aggressions, the main psycho-neuro-endocrine components of immune reaction regulation and modulation will be shown. Both central nervous structures that control the hormonal emissions, the vegetative innervation of the lymphoid organs as well as the afferent neurohumoral pathways involved in the making of the self-regulating and neuromodulating circuits of the humoral and cellular immune responses will be mentioned. An important position will be held by the interrelations between the hypothalamus-pituitary-corticoadrenal gland, the sympathetic-parasympathetic efferent pathways and the chemical messengers (hormones, neurotransmitters, interleukins, neurotrophins) which make possible the bi-directional neuroimmune communication for maintaining the homeostatic balances on this third effector pathway, too.

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