Publications by authors named "Daniela Bitencourt Leal"
Interferon gamma/interleukin-4 modulation, anti-inflammatory and antioxidant effects of hesperidin in complete Freund's adjuvant (CFA)-induced arthritis model of rats.
Stephen Adeniyi Adefegha Nathieli Bianchin Bottari Daniela Bitencourt Leal Cínthia Melazzo de Andrade Maria Rosa Schetinger
Immunopharmacol Immunotoxicol
October 2020
Background: This study sought to assess the effect of hesperidin on serum inflammatory cytokines and oxidative damage in liver of complete Freund's adjuvant (CFA)-induced arthritic rats.
Method: Fifty-six adult female Wistar rats (220-250 g) were acclimatized for two weeks. Intraplantar injection of CFA was done for the induction of arthritis and confirmed on the 14th day prior to oral administration of 40 and 80 mg/kg of hesperidin or dexamethasone for 45 days.