Efficacy and renal tolerability of ibuprofen vs. indomethacin in preterm infants with patent ductus arteriosus.

Indomethacin is commonly used for the treatment of patent ductus arteriosus (PDA) but has renal failure as a main side-effect. Ibuprofen seems to be efficient in closing the ductus with less side-effects, but few studies are available in literature as regards its use in preterm infants. This study is a retrospective analysis of clinical data in order to compare the efficacy and the renal tolerability of ibuprofen and indomethacin administered to preterm infants with gestational age (GA) < or = 30 weeks for the treatment of PDA.

In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure.

We report a case of neonatal transient renal failure after maternal ingestion of diclofenac, paracetamol, and nimesulide during pregnancy. The baby girl was delivered at the 33 weeks gestation for complete absence of amniotic fluid. Acute renal failure was present.

Vesicoureteral reflux in children: old and new approaches.

The clinical aspects of vesicoureteral reflux in children are analyzed, based on the different epidemiologic and clinical characteristics of the condition and its complications which include the possibility of chronic renal failure. According to the authors' personal experience, the modalities of approach to the problem are suggested.