Publications by authors named "Daniela B Bertoldo"
Quinolinic acid (QA) is a NMDA receptor agonist implicated in pathological conditions, such as neurodegenerative diseases and epilepsy. Time-course responses of different brain regions after QA i.c.
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- Statins, which inhibit cholesterol synthesis, have been studied for their potential neuroprotective effects, but their specific impacts on behavior are not well understood.
- Research analyzed the effects of atorvastatin and simvastatin on mice's cognitive performance through various tests; both drugs improved performance in the object location test without altering other behavioral responses.
- The cognitive benefits observed were linked to beta-adrenergic receptor modulation, suggesting that statins like atorvastatin and simvastatin may enhance spatial memory in rodents.
Objectives: Aloysia gratissima aqueous extract (AE) was investigated as a putative protective agent against quinolinic acid (QA)-induced seizures in mice and hippocampal cell damage. Additionally, AE and ferulic acid (FA), the major compound of AE, were tested against neurotoxicity evoked by glutamate or its N-methyl-D-aspartate receptor (NMDAR) agonist, QA on hippocampal slices, in vitro.
Methods: Mice were treated with AE before QA infusion (36.
Article Synopsis
- Oxygen-glucose deprivation (OGD) in brain cells increases glutamate levels, leading to excitotoxicity due to decreased uptake by transporters affected by oxidative stress.
- Atorvastatin, a cholesterol-lowering drug, shows potential neuroprotective effects by enhancing cell viability in brain slices following OGD and reoxygenation, likely by reducing oxidative stress.
- The protective effects of atorvastatin involve improving glutamate uptake and glutamine synthetase activity, and its efficacy depends on its ability to inhibit cholesterol synthesis.