Publications by authors named "Daniela Antenucci"
Article Synopsis
- This study investigates whether adding pioglitazone or sulfonylureas to metformin improves cardiovascular outcomes in patients with type 2 diabetes who don't achieve good control with metformin alone.
- Conducted as a multicenter trial in Italy, it involved 3028 patients aged 50-75 over a median follow-up of about 57 months.
- The trial was halted early due to futility, with only 105 patients experiencing the primary cardiovascular outcome during the study period.
The aim of the study was to assess whether HbA(1c) levels reflected mean blood glucose (MBG) levels in Type 2 diabetes. Despite the good correlation between HbA(1c) and MBG, one-third of the patients had consistently higher HbA(1c) or lower HbA(1c) levels than that expected under the hypothesis that HbA(1c) is solely determined by MBG, suggesting the existence of different haemoglobin glycation phenotypes. The use of HbA(1c) alone for glycemic control monitoring in these patients could be insufficient to clearly trace their risk of complications.
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