Effect of Three Hypopnea Scoring Criteria on OSA Prevalence and Associated Comorbidities in the General Population.

Study Objectives: Apnea-hypopnea index (AHI) is the main polysomnographic measure to diagnose obstructive sleep apnea (OSA). We aimed to evaluate the effect of three standard hypopnea definitions on the prevalence of OSA and its association with cardiometabolic outcomes in the general population.

Methods: We analyzed data from the HypnoLaus study (Lausanne, Switzerland), in which 2,162 participants (51% women, 57 ± 19 years) underwent in-home full polysomnography.

Prevalence and Clinical Significance of Respiratory Effort-Related Arousals in the General Population.

Study Objectives: To determine the prevalence and clinical associations of respiratory effort-related arousals (RERA) in a general population sample.

Methods: A total of 2,162 participants (51.2% women, 58.

Impact of sex and menopausal status on the prevalence, clinical presentation, and comorbidities of sleep-disordered breathing.

Objective: Sleep-disordered breathing (SDB) is currently considered as a unique condition, but it has been suggested that the prevalence, clinical presentation, and associated conditions may differ by sex or by menopausal status in women. We aimed to assess the prevalence of SDB and associated comorbidities in pre- and postmenopausal women compared with men.

Methods: Participants of the population-based HypnoLaus Sleep Cohort study underwent polysomnography in their home environment and had extensive phenotyping for diabetes, hypertension, metabolic syndrome, and depression.

REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort.

This study determined the prevalence of rapid eye movement (REM) related sleep-disordered breathing (REM-SDB) in the general population and investigated the associations of REM-SDB with hypertension, metabolic syndrome, diabetes and depression.Home polysomnography (PSG) recordings (n=2074) from the population-based HypnoLaus Sleep Cohort (48.3% men, 57±11 years old) were analysed.

Clinical significance of periodic limb movements during sleep: the HypnoLaus study.

Objective: Periodic limb movements during sleep (PLMS) are prevalent in the general population, but their impact on sleep and association with cardiometabolic disorders are a matter of debate.

Methods: Data from 2162 participants (51.2% women, mean age 58.

Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population.

Study Objectives: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely unknown. This study determined the prevalence and characteristics of RBD in the general population using gold-standard polysomnography.

Sleep characteristics and cognitive impairment in the general population: The HypnoLaus study.

Objective: To assess the association between sleep structure and cognitive impairment in the general population.

Methods: Data stemmed from 580 participants aged >65 years of the population-based CoLaus/PsyCoLaus study (Lausanne, Switzerland) who underwent complete sleep evaluation (HypnoLaus). Evaluations included demographic characteristics, personal and treatment history, sleep complaints and habits (using validated questionnaires), and a complete polysomnography at home.

Prevalence and determinants of periodic limb movements in the general population.

Objective: Periodic limb movements during sleep (PLMS) are sleep phenomena characterized by periodic episodes of repetitive stereotyped limb movements. The aim of this study was to describe the prevalence and determinants of PLMS in a middle to older aged general population.

Methods: Data from 2,162 subjects (51.

Sleep-Disordered Breathing and Vascular Function in Patients With Chronic Mountain Sickness and Healthy High-Altitude Dwellers.

Background: Chronic mountain sickness (CMS) is often associated with vascular dysfunction, but the underlying mechanism is unknown. Sleep-disordered breathing (SDB) frequently occurs at high altitude. At low altitude, SDB causes vascular dysfunction.

Bad sleep? Don't blame the moon! A population-based study.

Introduction: The aim of this study was to evaluate if there is a significant effect of lunar phases on subjective and objective sleep variables in the general population.

Methods: A total of 2125 individuals (51.2% women, age 58.

Scoring criteria for portable monitor recordings: a comparison of four hypopnoea definitions in a population-based cohort.

Rationale: Limited-channel portable monitors (PMs) are increasingly used as an alternative to polysomnography (PSG) for the diagnosis of obstructive sleep apnoea (OSA). However, recommendations for the scoring of PM recordings are still lacking. Pulse-wave amplitude (PWA) drops, considered as surrogates for EEG arousals, may increase the detection sensitivity for respiratory events in PM recordings.

Age and gender variations of sleep in subjects without sleep disorders.

Objective: Although sleep is a biomarker for general health and pathological conditions, its changes across age and gender are poorly understood.

Methods: Subjective evaluation of sleep was assessed by questionnaires in 5,064 subjects, and 2,966 were considered without sleep disorders. Objective evaluation was performed by polysomnography in 2,160 subjects, and 1,147 were considered without sleep disorders.

Objective sleep structure and cardiovascular risk factors in the general population: the HypnoLaus Study.

Study Objectives: To evaluate the association between objective sleep measures and metabolic syndrome (MS), hypertension, diabetes, and obesity.

Design: Cross-sectional study.

Setting: General population sample.

Effect of transnasal insufflation on sleep disordered breathing in acute stroke: a preliminary study.

Background And Purpose: Sleep disordered breathing (SDB) is frequent in acute stroke patients and is associated with early neurologic worsening and poor outcome. Although continuous positive airway pressure (CPAP) effectively treats SDB, compliance is low. The objective of the present study was to assess the tolerance and the efficacy of a continuous high-flow-rate air administered through an open nasal cannula (transnasal insufflation, TNI), a less-intrusive method, to treat SDB in acute stroke patients.

Reaction time performance in upper airway resistance syndrome versus obstructive sleep apnea syndrome.

Background: Patients with obstructive sleep apnea syndrome (OSAS) are known to have an increased risk for motor vehicle crashes. They suffer from sleep-related respiratory abnormality causing repetitive arousal leading to daytime sleepiness. In turn, it has been demonstrated that sleepiness can impair human psychomotor performance causing slowing of reaction times (RTs).