High Expression of MRE11A Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients.

Background: Homologous recombination repair (HR) is the most accurate repair pathway for double-strand breaks and replication fork disruption that is capable of faithfully restoring the original nucleotide sequence of the broken DNA. The deficiency of this mechanism is a frequent event in tumorigenesis. Therapies that exploit defects in HR have been explored essentially in breast, ovarian, pancreatic, and prostate cancers, but poorly in colorectal cancers (CRC), although CRC ranks second in mortality worldwide.

Endoscopic Treatment Using the Padlock Clip System for Rectourethral Fistula After Prostatectomy.

We present a case of a 68-year-old man with a rectourethral fistula (RUF) successfully treated with a unique endoscopic approach using the Padlock Clip system (Steris, Basingstoke, UK). This is a complex case of a patient who, after radical prostatectomy, continued to show several complications, including fistulas and relapses. Our work aims to enhance the literature with our technique and to help the scientific community in future RUF cases.

Retrorectal Bronchogenic Cyst With a Sacrococcygeal Surgical Approach.

We present a case of a bronchogenic cyst in the retrorectal space that was successfully treated with a unique sacrococcygeal surgical approach, thus avoiding abdominal access. This report aims to enhance the literature with our technique and to help the scientific community in treating future retrorectal bronchogenic cyst cases. A 19-year-old man presented to the hospital with testicular pain refractory to over-the-counter analgesics.