UHPLC-DAD/ESI-TOF-MS Phytochemical Characterization and Evaluation of the Impact of Fruit Intractum on Biochemical, Hepatological, and Blood Parameters in Balb/c Mice.

(Rupr. et Maxim.) Maxim.

Ethyl Acetate Fraction from Root Extract as a Promising Source of Compounds with Anti-Hyaluronidase, Anti-Tyrosinase, and Antioxidant Activity but Not Anti-Melanoma Activity.

(Siebold and Zucc.) S. Y.

Fruits Decrease Hyaluronidase Activity in Blood Serum and Protect from Antioxidative Damages in In Vitro Model.

Fruits are very important dietary components and a source of biologically active compounds used in nutritional pharmacology. Particularly due to the presence of polyphenolic compounds, fruits play an important role in the prevention of diseases of civilization. Therefore, it is important to study the phytochemicals and biological activity of fruits, especially those with a long-standing use in ethnomedicine.

The Eleutherococcus senticosus fruits' intractum affects changes in the transepithelial electric potential in the distal section of the rabbit's large intestine and inhibits hyaluronidase.

Ethnopharmacological Relevance: Eleutherococcus senticosus (Rupr. et Maxim.) Maxim.

Evaluation of the yield, chemical composition and biological properties of essential oil from bioreactor-grown cultures of Salvia apiana microshoots.

Microshoot cultures of the North American endemic Salvia apiana were established for the first time and evaluated for essential oil production. Stationary cultures, grown on Schenk-Hildebrandt (SH) medium, supplemented with 0.22 mg/L thidiazuron (TDZ), 2.

Phenolic Profile, Antioxidant, Anti-Enzymatic and Cytotoxic Activity of the Fruits and Roots of (Rupr. et Maxim.) Maxim.

(Rupr. et Maxim.) Maxim.

Effectiveness and patient satisfaction of dental emergencies in Pitié Salpêtrière Hospital, Paris, during the COVID 19 pandemic.

Background: A previous study reported the effectiveness and patient satisfaction in the dental emergency unit (DEU) of the Pitie Salpetrière Hospital in Paris before coronavirus disease 2019 (COVID-19). The same methodology was used during the COVID-19 pandemic to compare pain, anxiety, and patient satisfaction during the two periods.

Methods: This prospective study was conducted in 2020 (NCT04354272) on adult patients.

Phenolic acids as chemotaxonomic markers able to differentiate the Euphrasia species.

The objective of this study was to get the answer on the question, which phenolic compounds may serve as chemical markers in taxonomy of Euphrasia spp. (E. nemorosa, E.

Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Isoquinoline Alkaloids.

The plant is rich in biologically active isoquinoline alkaloids. These alkaline polar compounds are isolated from raw materials with the use of acidified water or methanol; next, after alkalisation of the extract, they are extracted using chloroform or dichloromethane. This procedure requires the use of toxic solvents.

Paving the way towards effective plant-based inhibitors of hyaluronidase and tyrosinase: a critical review on a structure-activity relationship.

Human has used plants to treat many civilisation diseases for thousands of years. Examples include reserpine (hypertension therapy), digoxin (myocardial diseases), vinblastine and vincristine (cancers), and opioids (palliative treatment). Plants are a rich source of natural metabolites with multiple biological activities, and the use of modern approaches and tools allowed finally for more effective bioprospecting.

Multidirectional anti-melanoma effect of galactolipids (MGDG-1 and DGDG-1) from Impatiens parviflora DC. and their synergy with doxorubicin.

The anti-melanoma potential of galactolipids: MGDG-1 and DGDG-1, isolated from Impatiens parviflora, and their synergistic effect with anticancer drug - doxorubicin (DOX) was investigated. Both compounds demonstrated time- and dose-dependent cytotoxicity against human melanoma cells of different metastatic potential. MGDG-1 was more effective than DGDG-1, with the highest activity against A375 cell line (IC = 15.

Dataset of the next-generation sequencing of variable 16S rRNA from bacteria and ITS2 regions from fungi and plants derived from honeybees kept under anthropogenic landscapes.

Forager honeybees were collected from four localities located in Europe, i.e.: London, UK; Athens, Greece; Marchamalo, Spain and Lublin, Poland.

Amplicon Sequencing of Variable 16S rRNA from Bacteria and ITS2 Regions from Fungi and Plants, Reveals Honeybee Susceptibility to Diseases Results from Their Forage Availability under Anthropogenic Landscapes.

European and Asian honeybees are essential crop pollinators. Microbiome studies can provide complex information on health and fitness of these insects in relation to environmental changes, and plant availability. Amplicon sequencing of variable regions of the 16S rRNA from bacteria and the internally transcribed spacer (ITS) regions from fungi and plants allow identification of the metabiome.

Pharmacognostic Evaluation and HPLC-PDA and HS-SPME/GC-MS Metabolomic Profiling of Fruits.

(Rupr. et Maxim.) Maxim.

The intractum from the Eleutherococcus senticosus fruits affects the innate immunity in human leukocytes: From the ethnomedicinal use to contemporary evidence-based research.

Ethnopharmacological Relevance: In the ethnomedicine of Russia, the Eleutherococcus senticosus (Rupr. et Maxim.) Maxim.

Extracts from (Rupr. et Maxim.) Maxim. Roots: A New Hope Against Honeybee Death Caused by Nosemosis.

Pollinators, the cornerstones of our terrestrial ecosystem, have been at the very core of our anxiety. This is because we can nowadays observe a dangerous decline in the number of insects. With the numbers of pollinators dramatically declining worldwide, the scientific community has been growing more and more concerned about the future of insects as fundamental elements of most terrestrial ecosystems.

Species Cultivated in Europe: A New Source of Compounds with Antiacetylcholinesterase, Antihyaluronidase, Anti-DPPH, and Cytotoxic Activities.

Secondary metabolites of the roots of spp. cultivated in Poland, or the bioactivity, are not fully known. The 75% methanol extracts of five spp.

Polysaccharide-Rich Fractions from Thunb.-Composition and Chemopreventive Potential.

The huge health-beneficial potential of polysaccharides encourages the search for novel sources and applications of these compounds. One poorly explored source of polysaccharides is the rose. The content and biological activity of polysaccharides in rose organs is an almost completely unaddressed topic, therefore, polysaccharide-rich extracts (crude polysaccharides, CPLs) from petals, leaves, hips, and achenes of Thunb.

Historical and traditional medical applications of Carlina acaulis L. - A critical ethnopharmacological review.

Ethnopharmacological Relevance: The genus Carlina (Asteraceae) comprises approx. 30 plant species growing in Europe and Asia. Carlina acaulis L.

Antilisterial Activity of Polypropylene Film Coated with Chitosan with Propolis and/or Bee Pollen in Food Models.

The aim of the study was to evaluate the effect of propylene film coated with solution of chitosan (CH), ethanolic extracts of propolis (EEP), and bee pollen (EEBP) and its combination on number in wrapped salmon, salami, and cheese. Sterile fragments of propylene film were coated with solution containing CH, CH+EEP, CH+EEBP, and CH+EEP+EEBP. The coated film was applied directly after preparation (AP) after 10 days of storage from preparation (AS).

Effects of Glutathione on Hydrolytic Enzyme Activity in the Mouse Hepatocytes.

In this study, the effect of glutathione (GSH) on the activity of hydrolytic enzymes of lysosomal, microsomal, and cytosolic fractions was studied in the mouse hepatocytes. The experiments involved 30 Swiss male mice, divided into the experimental and control groups of 15 mice each. The former group received injections of 12 μL/g of GSH solution at a dose of 100 μg/g body weight, whereas the latter received 12 μL/g of physiological saline, all given intraperitoneally daily for 7 days.

Changes in the bioelement content of summer and winter western honeybees (Apis mellifera) induced by Nosema ceranae infection.

Proper bioelement content is crucial for the health and wellness of all organisms, including honeybees. However, the situation is more complicated in these important pollinators due to the fact that they change their physiology during winter in order to survive the relatively harsh climatic conditions. Additionally, honeybees are susceptible to many diseases such as nosemosis, which during winter can depopulate an entire colony.

The impact of ethanol extract of propolis on biofilm forming by strains isolated from chronic wounds infections.

Alcoholic propolis extracts may be used to eliminate microbes in mucous membranes and skin inflammations and in wound infections. The aim of this study was an assessment of the ethanol extract of propolis (EEP) activity against biofilm formation by . Six clinical strains of isolated from patients with chronic wound infection, and one reference strain of ATCC 29906 were used.