Primary Congenital Hypothyroidism in Children Below 3 Years Old - Etiology and Treatment With Overtreatment and Undertreatment Risks, a 5-Year Single Centre Experience.

Worldwide neonatal screening for congenital hypothyroidism (CH) is a gold standard of active surveillance in newborns. Prompt diagnosis, subsequent timely treatment implementation, and proper dosage of levothyroxine (L-T4) are crucial for normal growth and development, especially of the central nervous system. However, overtreatment may have a potential negative impact on further neurodevelopment.

[Glucokinase gene mutation as a causative factor of permanent neonatal diabetes mellitus].

Introduction: The most frequent type of diabetes in childhood is type 1 diabetes. Thanks to the development of genetic testing, the rare monogenic forms of that disease have been defined. One of them is neonatal diabetes identified within the first 6 months of life and often associated with the mutation in KCNJ11, ABCC8 or insulin gene.

Adverse drug event rates in six community hospitals and the potential impact of computerized physician order entry for prevention.

Context: Medications represent a major cause of harm and are costly for hospitalized patients, but more is known about these issues in large academic hospitals than in smaller hospitals.

Objective: To assess the incidence of adverse drug events (ADEs) in six community hospitals.

Design: Multicenter, retrospective cohort study.

Occurrence of adverse, often preventable, events in community hospitals involving nephrotoxic drugs or those excreted by the kidney.

Medication errors in patients with reduced creatinine clearance are harmful and costly; however, most studies have been conducted in large academic hospitals. As there are few studies regarding this issue in smaller community hospitals, we conducted a multicenter, retrospective cohort study in six community hospitals (100 to 300 beds) to assess the incidence and severity of adverse drug events (ADEs) in patients with reduced creatinine clearance. A chart review was performed on adult patients hospitalized during a 20-month study period with serum creatinine over 1.

[Evaluation of lipids, lipoproteins and apolipoproteins in the blood serum of children with type 1 diabetes].

Background: Children and youth with type 1 diabetes have a higher risk of atherosclerosis. Therefore all of the atherosclerosis risk factors should be observed in those children early. The disorders of lipid metabolism are characteristic and their intensification depends on the type of diabetes and its balance.