Publications by authors named "Daniel Weingrad"

Article Synopsis
  • Recent studies suggest there's no significant difference in long-term survival between head and neck melanoma patients receiving only sentinel lymph node biopsy (SLNB) versus those also undergoing completion lymph node dissection (CLND).
  • An analysis of 634 patients with SLNB+ showed similar overall survival rates in both treatment groups, regardless of various risk factors like lymphovascular invasion, comorbidities, or whether patients received immunotherapy.
  • The findings indicate that for HN melanoma patients, CLND does not necessarily improve outcomes over SLNB alone, highlighting the need for more research to clarify the role of CLND in treatment.
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Introduction: This study's purpose was to characterize tissue dielectric constant (TDC) values of malignant and benign breast tumors and assess the potential utility of TDC differentials to help distinguish between malignant and benign tumors.

Methods: Prior to their diagnostic biopsy, TDC was measured at 300 MHz in 59 women with previously detected breast tumors. TDC measurements were made by touching skin directly over the tumor and on the non-affected breast with a hand-held 22 mm diameter probe.

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Many methods can quantitatively assess limb lymphedema, but methods to assess breast edema/lymphedema are quite limited. Thus, there is a need for a convenient and accurate way to quantify and track changes in this condition. Herein, breast tissue dielectric constant (TDC) values that depend on tissue water were used to obtain reference TDC values and interbreast TDC ratios.

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Breast cancer is the most common cancer in women, and the leading cause of cancer-related deaths worldwide. Despite advances in screening and treatment modalities, distant metastasis still develops. Breast cancer metastasis to the gastrointestinal tract is very rare, therefore, its diagnosis, therapeutic strategies, and prognosis pose a clinical problem for clinicians.

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Background: Our goal was to characterize temporal patterns of skin Tissue Dielectric Constant (TDC) as a foundation for possible TDC use to detect and quantify lymphedema. Although limb volumes and bioimpedance analysis (BIA) are used for this purpose, potential TDC-method advantages are that it can be done in about 10 seconds at any body site to depths from 0.5 to 5.

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Background: Skin-to-fat tissue dielectric constant (TDC) values at 300 MHz largely depend on tissue water and provide a rapid way to assess skin water by touching skin with a probe for approximately 10 s. This method has been used to investigate lymphedema features accompanying breast cancer (BC), but relationships between TDC and nodes removed or symptoms is unclear. Our goals were: (1) to compare TDC values in BC patients prior to surgery (group A) and in patients who had BC-related surgery (group B) to determine if TDC of group B were related to nodes removed and reported symptoms and (2) to develop tentative lymphedema-detection thresholds.

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Background: Quantitative measurements to help detect incipient or latent lymphedema in patients at risk for breast cancer treatment-related lymphedema (BCRL) are potentially useful supplements to clinical assessments. Suitable measurements for routine use include arm volumes, arm bioimpedance, and local tissue water (LTW) determined from the tissue dielectric constant (TDC). Because BCRL initially develops in skin and subcutis, measures that include whole arms may not be optimally sensitive for detecting the earliest changes.

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