Publications by authors named "Daniel Weed"
Article Synopsis
- The study investigates whether adding metastasis-directed therapy (MDT) to standard-of-care (SOC) systemic therapy improves progression-free survival (PFS) in patients with oligometastatic breast cancer.
- A phase II randomized trial, EXTEND, included patients with up to five metastases and compared MDT plus SOC to SOC alone, measuring outcomes such as PFS and overall survival (OS).
- Results from 43 patients showed no significant improvement in PFS or other secondary endpoints with MDT, suggesting it may not provide additional benefit for this patient group, albeit with limitations in study size and sample diversity.
Background: The purpose of this study is to review our experience with the use of IORT for patients with advanced cervical metastasis.
Methods: Between August 1982 and July 2007, 231 patients underwent neck dissections as part of initial therapy or as salvage treatment for advanced cervical node metastases resulting from head and neck malignancies. IORT was administered as a single fraction to a dose of 15 Gy or 20 Gy in most pts.
Intraoperative radiotherapy for parotid cancer: a single-institution experience.
Int J Radiat Oncol Biol Phys
April 2012
Purpose: Our practice policy has been to provide intraoperative radiotherapy (IORT) at resection to patients with head-and-neck malignancies considered to be at high risk of recurrence. The purpose of the present study was to review our experience with the use of IORT for primary or recurrent cancer of the parotid gland.
Methods And Materials: Between 1982 and 2007, 96 patients were treated with gross total resection and IORT for primary or recurrent cancer of the parotid gland.
Patient preferences and physician practice patterns regarding breast radiotherapy.
Int J Radiat Oncol Biol Phys
February 2012
Purpose: There are multiple current strategies for breast radiotherapy (RT). The alignment of physician practice patterns with best evidence and patient preferences will enhance patient autonomy and improve cancer care. However, there is little information describing patient preferences for breast RT and physician practice patterns.
View Article and Find Full Text PDFPurpose: We report the first single-institutional dosimetric comparison of patients treated with three forms of accelerated partial breast irradiation: interstitial HDR brachytherapy, the MammoSite balloon apparatus, and 3D conformal external beam quadrant irradiation (3D-CRT).
Methods: A retrospective dosimetric comparison of interstitial HDR brachytherapy, MammoSite balloon brachytherapy, and 3D-CRT was performed. Thirty patients including 10 from each treatment technique were included for a dosimetric comparison of the dose received by the ipsilateral breast, PTV, heart, and ipsilateral lung.
Purpose: We hypothesize that surgical clips placed in the biopsy cavity during lumpectomy can be used as radiographic markers to facilitate image-guided external beam accelerated partial breast irradiation.
Methods And Materials: We evaluated 28 patients with surgically placed clips in the lumpectomy cavity and two CT scans on different days. To establish whether the clips remain predictive of the lumpectomy cavity throughout therapy, we analyzed the motion of both cavities with repeat volumetric CT scans.