Zebrafish extracellular matrix improves neuronal viability and network formation in a 3-dimensional culture.

Mammalian central nervous system (CNS) has limited capacity for regeneration. CNS injuries cause life-long debilitation and lead to $50 billion in healthcare costs in U.S.

Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration.

Heart attack is a global health problem that leads to significant morbidity, mortality, and health care burden. Adult human hearts have very limited regenerative capability after injury. However, evolutionarily primitive species generally have higher regenerative capacity than mammals.