Publications by authors named "Daniel Vieira Martins"
Geraniol inhibits both planktonic cells and biofilms of the Candida parapsilosis species complex: Highlight for the improved efficacy of amphotericin B, caspofungin and fluconazole plus Geraniol.
José Júlio Costa Sidrim Daniel Vieira Martins Maria Gleiciane da Rocha Géssica Dos Santos Araújo Rossana de Aguiar Cordeiro
Med Mycol
November 2024
Article Synopsis
- The Candida parapsilosis species complex is a significant concern in healthcare settings due to rising antifungal resistance.
- Geraniol, a terpene from essential oils, has demonstrated potential antimicrobial effects against this yeast species in both planktonic and biofilm forms.
- In lab tests, geraniol showed an effective minimum inhibitory concentration (MIC) between 256-512 µg/ml and reduced biofilm activity, while also enhancing the effectiveness of certain antifungal medications like amphotericin B and fluconazole.
Paraquat (1,10-dimethyl-4,4-bipyridinium dichloride; PQ) is a free-radical producing herbicide that affects cell membranes and can upset the environmental balance of microorganisms present in soil, such as spp. This study aimed to evaluate the in vitro activity of PQ against spp. in planktonic and biofilm forms, as well as the protective effect of antioxidant agents against the antifungal effect of PQ and the kinetics of melanin production in response to PQ.
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