Formulation of Antioxidant Composites by Controlled Heteroaggregation of Cerium Oxide and Manganese Oxide Nanozymes.

Antioxidant composites based on nanozymes [manganese oxide microflakes (MnO MFs) and cerium oxide nanoparticles (CeO NPs)] were formulated by controlled heteroaggregation. The interparticle attraction via electrostatic forces was systematically tuned with surface functionalization by the poly(diallyldimethyl chloride) (PDADMAC) polyelectrolyte. The PDADMAC-coated MnO MFs (PMn) were heteroaggregated with oppositely charged CeO NPs to generate the Ce-PMn composite, while the PDADMAC-functionalized CeO NPs (PCe) were immobilized onto bare MnO MFs, resulting in the Mn-PCe composite.