Essential oil from Ocimum basilicum improves growth performance and does not alter biochemical variables related to stress in pirarucu (Arapaima gigas).

Diet supplementation with essential oil from sweet basil Ocimum basilicum (EOOB) can increase fish growth. So, this study aimed to evaluate the effect of EOOB in the diet on growth performance and plasmatic variables of pirarucu juveniles (Arapaima gigas) submitted to stressful condition (stocking density of 7.56 kg m-3per tank and limited space).

Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi.

[1,2,3]-Triazole derivatives of nor-beta-lapachone were synthesized and assayed against the infective bloodstream trypomastigote form of Trypanosoma cruzi, the etiological agent of Chagas disease. All the derivatives were more active than the original quinones, with IC(50)/1 day values in the range of 17 to 359 microM, the apolar phenyl substituted triazole 6 being the most active compound. These triazole derivatives of nor-beta-lapachone emerge as interesting new lead compounds in drug development for Chagas disease.

Synthesis of naphthofuranquinones with activity against Trypanosoma cruzi.

Four new naphthofuranquinones, obtained from 2-hydroxy-3-allyl-naphthoquinone (1) and nor-lapachol (2), have their structures established by physical and X-ray analysis and their activity evaluated against Trypanosoma cruzi. Compounds 3 and 4 were obtained by addition of iodine to 1 followed by cyclization generating a furan ring. Compound 5 was obtained through the acid-catalyzed reaction by dissolution of 1 in sulfuric acid.