Publications by authors named "Daniel Tornberg"

Article Synopsis
  • - A study investigated the effects of high-dose inhaled nitric oxide on improving oxygen levels in adults with severe COVID-19 related respiratory failure by comparing it to standard care.
  • - Results showed that the inhaled nitric oxide group had a greater increase in the Pa/Fi ratio (oxygen levels) at 48 hours and had a higher proportion of participants reaching satisfactory oxygen levels at 28 days compared to the control group.
  • - Although inhaled nitric oxide improved oxygenation, there were no significant differences in survival rates and ventilation duration at 28 or 90 days, and no serious adverse effects were reported.
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Background: Parturients undergoing caesarean section in general anaesthesia have an increased risk of desaturating during anaesthesia induction. Pre- and peri-oxygenation with high-flow nasal oxygen prolong the safe apnoea time but data on parturients undergoing caesarean section under general anaesthesia are limited. This pilot study aimed to investigate the clinical effects and frequency of desaturation in parturients undergoing caesarean section in general anaesthesia pre- and peri-oxygenated with high-flow nasal oxygen and compare this to traditional pre-oxygenation using a facemask.

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Background: Fluid bolus therapy (FBT) is common in ICUs but whether it achieves the effects expected by intensivists remains uncertain. We aimed to describe intensivists' expectations and compare them to the actual physiological effects.

Methods: We evaluated 77 patients in two ICUs (Sweden and Australia).

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Objective: Clinical and experimental data indicate that when there is lung disease, wedging the pulmonary artery catheter (PAC) could cause decreases in cardiac output and systemic arterial blood pressure and an increase in mean pulmonary artery pressure (PAP). The authors studied whether wedging would alter mean left atrial pressure (LAP), and report perforations with PACs in their unit since 1975.

Design: Observational study.

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Objective: Nitrite in saliva is reduced to nitric oxide (NO) in the acidic stomach, and this NO may serve gastroprotective functions. We studied intragastric NO levels in healthy controls and in intubated intensive care unit patients before and after supplementation with nitrite.

Design: Prospective observational study involving patients and controls.

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Multiple flow rate measurements of exhaled nitric oxide (NO) have been advocated to fractionate NO from alveolar and bronchial sources. The aim of this study was to develop a method by which multiple single-breath exhalations at various flow rates could be performed in intubated, mechanically ventilated patients. Nine patients without lung disease were studied awake and after intubation, during general anesthesia.

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Direct measurements of endogenous nitric oxide (NO) release is of great interest but difficult to perform in vivo. We hypothesized that endogenous NO release from vasoactive substances would be detectable in exhaled air. Exhaled NO was measured after intravenous injections of various endothelium-dependent and endothelium-independent vasoactive drugs, in anesthetized pigs and humans.

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