Publications by authors named "Daniel Toddie-Moore"
Background: Primary ciliary dyskinesia (PCD) is a genetic disorder affecting motile cilia. Most cases are inherited recessively, due to variants in >50 genes that result in abnormal or absent motile cilia. This leads to chronic upper and lower airway disease, subfertility, and laterality defects.
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- Ehlers-Danlos syndromes (EDS) are genetic disorders that affect connective tissue, and there are 13 different types of EDS.
- Researchers studied 174 EDS patients who didn't have a clear genetic diagnosis to find out more about their conditions using advanced genetic testing called whole exome sequencing (WES).
- They discovered several genetic variants related to EDS and other similar disorders, showing that more research and better testing can help identify difficult cases and improve diagnosis.
Developmental patterning is thought to be regulated by conserved signalling pathways. Initial patterns are often broad before refining to only those cells that commit to a particular fate. However, the mechanisms by which pattern refinement takes place remain to be addressed.
View Article and Find Full Text PDFAt the level of organ formation, tissue morphogenesis drives developmental processes in animals, often involving the rearrangement of two-dimensional (2D) structures into more complex three-dimensional (3D) tissues. These processes can be directed by growth factor signaling pathways. However, little is known about how such morphological changes affect the spatiotemporal distribution of growth factor signaling.
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