Varenicline induces manic relapse in bipolar disorder.

Varenicline (Chantix) is commonly used to assist individuals with smoking cessation. This medication is known to affect mood and behavior. We report a patient with bipolar disorder who developed manic relapse after starting treatment with varenicline for tobacco dependence.

Efficacy and safety of bupropion for smoking cessation and reduction in schizophrenia: systematic review and meta-analysis.

Background: The benefits and harms of bupropion as an aid for smoking cessation in schizophrenia remain uncertain.

Aims: To summarise the current evidence for efficacy and safety of bupropion as treatment for nicotine dependence in schizophrenia.

Method: Systematic review and random-effects meta-analysis of randomised controlled trials (RCTs) comparing bupropion with placebo or alternative therapeutic control in adult smokers with schizophrenia.