Development of evidence-based quality indicators for deep brain stimulation in patients with Parkinson's disease and first year experience of implementation of a nation-wide registry.

Introduction: Deep Brain Stimulation (DBS) is a complex, invasive and cost-intensive therapy that requires a high level of expertise. To date, data on quality of DBS in clinical routine in the German health care system are lacking.

Methods: The development of evidence-based QIs for DBS in PD patients was performed following a standardized process by a multidisciplinary board between 2014 and 2016.

Controlling Coordination Geometries: Ru-Carbene Complexes with Tetra-NHC Ligands.

The synthesis of the first ruthenium(II) complexes bearing open-chain tetra-N-heterocyclic carbene (tetra-NHC) ligands via in situ transmetalation is described. The ruthenium complexes show differing coordination geometries depending on the length of the alkyl linker. Replacement of the two cis acetonitrile ligands in the methylene bridged ruthenium complex by nucleophiles also influences the coordination geometry.

Exploring Coordination Modes: Late Transition Metal Complexes with a Methylene-bridged Macrocyclic Tetra-NHC Ligand.

A tetranuclear silver(I) N-heterocyclic carbene (NHC) complex bearing a macrocyclic, exclusively methylene-bridged, tetracarbene ligand was synthesized and employed as transmetalation agent for the synthesis of nickel(II), palladium(II), platinum(II), and gold(I) derivatives. The transition metal complexes exhibit different coordination geometries, the coinage metals being bound in a linear fashion forming molecular box-type complexes, whereas the group 10 metals adapt an almost ideal square planar coordination geometry within the ligand's cavity, resulting in saddle-shaped complexes. Both the Ag(I) and the Au(I) complexes show ligand-induced metal-metal contacts, causing photoluminescence in the blue region for the gold complex.

Structural diversity of late transition metal complexes with flexible tetra-NHC ligands.

The synthesis of copper, gold, nickel, palladium, platinum, and iron complexes with open chain tetra-N-heterocyclic carbene (NHC) ligands via transmetalation using silver NHC complexes is presented. The obtained complexes show differing coordination geometries depending on both ligand structure and metal. While the complexes of the coinage metals form di- or tetranuclear structures, the group 10 metal complexes exhibit a distorted square planar coordination geometry at the metal centers.

Application of open chain tetraimidazolium salts as precursors for the synthesis of silver tetra(NHC) complexes.

The synthesis of 3-((1H-imidazol-1-yl)methyl)-1-methyl-1H-imidazol-3-ium iodide 1 for the synthesis of multidentate tetra-N-heterocyclic carbene (NHC) structures is described. Two acyclic open chain tetra(NHC) precursors are synthesized together with their corresponding silver complexes. On the basis of nuclear magnetic resonance (NMR) spectroscopy and single crystal X-ray diffraction (XRD) data, the coordination geometry of the silver complexes is discussed.