Lysosomal NKG7 restrains mTORC1 activity to promote CD8 T cell durability and tumor control.

During infection and cancer, mTORC1-mediated metabolic regulation impacts CD8 T cell effector expansion and memory development. However, the mechanisms by which CD8 T cells regulate mTORC1 to support their unique metabolic requirements remain unknown. Here we show that NKG7, a lysosomal protein whose expression is restricted to cytotoxic lymphocytes, negatively regulates mTORC1 recruitment and activation by inhibiting assembly and function of the lysosomal proton pump, vacuolar ATPase (v-ATPase).