Publications by authors named "Daniel Sossau"
Background: In the context of malaria elimination/eradication, drugs that are effective against the different developmental stages of the parasite are highly desirable. The oldest synthetic anti-malarial drug, the thiazine dye methylene blue (MB), is known for its activity against Plasmodium blood stages, including gametocytes. The aim of the present study was to investigate a possible effect of MB against malaria parasite liver stages.
View Article and Find Full Text PDFInterferon-α (INF-α) is used as an adjuvant treatment for high-risk cutaneous melanoma. It has a large variety of potentially severe and irreversible side effects and can contribute toward the development of autoimmune disease. We report a case of a 59-year-old woman who developed type 1 diabetes following the use of low-dose IFN-α for the adjuvant treatment of stage IIB melanoma.
View Article and Find Full Text PDFArticle Synopsis
- The dormant liver stage of the malaria parasite Plasmodium vivax, known as hypnozoites, complicates efforts to control and eradicate malaria due to their poorly understood molecular makeup.
- Researchers utilized advanced techniques to produce the first transcriptome of these hypnozoites, isolating them from infected monkey liver cells and optimizing RNA sequencing methods.
- The study identified 120 differentially expressed transcripts in hypnozoites compared to dividing liver stages and highlighted potential molecular markers and regulatory mechanisms important for the hypnozoite's dormant state.