It's not just what we don't know: The mapping problem in the acquisition of negation.

How do learners learn what no and not mean when they are only presented with what is? Given its complexity, abstractness, and roles in logic, truth-functional negation might be a conceptual accomplishment. As a result, young children's gradual acquisition of negation words might be due to their undergoing a gradual conceptual change that is necessary to represent those words' logical meaning. However, it's also possible that linguistic expressions of negation take time to learn because of children's gradually increasing grasp of their language.

Dominant functional role of the novel phosphorylation site S811 in the human renal NaCl cotransporter.

The NaCl cotransporter (NCC) is essential for electrolyte homeostasis and control of blood pressure. The human SLC12A3 gene, which encodes NCC, gives rise to 3 isoforms, of which only the shortest isoform [NaCl cotransporter isoform 3 (NCC)] has been studied extensively. All NCC isoforms share key phosphorylation sites at T55 and T60 that are essential mediators of NCC function.