Make It or Break It? Injury Impacts More Than Half of Deselected Athletes Who Dropped Out of the High-Performance Pathway System. A 4-Year Retrospective Cohort Study.

To investigate: (1) the injury epidemiology in an Australian academy; (2) how athletes transition through the high-performance sport (HPS) pathway; and (3) why athletes leave this HPS program. This retrospective cohort study was conducted at an Australian HPS academy over a 4-year period. Medical attention injuries were prospectively recorded.

Despite maintaining a high daily training availability, a quarter of athletes start the season injured and three quarters experience injury in an Australian State Academy of Sport.

Objectives: To 1) investigate the incidence, prevalence, burden and characteristics of injuries; and 2) explore the frequency of physiotherapy and medical servicing for elite sports academy athletes over a 12-month season.

Design: Prospective cohort study.

Methods: Medical attention and time-loss injuries were prospectively recorded by Physiotherapy and Medical (Sports Physician) staff for 94 athletes (72.

A Small-Molecule Inhibitor to the Cytokine Interleukin-4.

Interleukin-4 (IL-4) is a multifunctional cytokine and an important regulator of inflammation. When deregulated, IL-4 activity is associated with asthma, allergic inflammation, and multiple types of cancer. While antibody-based inhibitors targeting the soluble cytokine have been evaluated clinically, they failed to achieve their end points in trials.

Targeting Type 1 Diabetes: Selective Approaches for New Therapies.

The clinical onset of type 1 diabetes is characterized by the destruction of the insulin-producing β cells of the pancreas and is caused by autoantigen-induced inflammation (insulitis) of the islets of Langerhans. The current standard of care for type 1 diabetes mellitus patients allows for management of the disease with exogenous insulin, but patients eventually succumb to many chronic complications such as limb amputation, blindness, and kidney failure. New therapeutic approaches now on the horizon are looking beyond glycemic management and are evaluating new strategies from protecting and regenerating endogenous islets to treating the underlying autoimmunity through selective modulation of key immune cell populations.

Sustained activation of ERK1/2 MAPK in Schwann cells causes corneal neurofibroma.

Recent studies have shown that constitutive activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in Schwann cells (SCs) increases myelin thickness in transgenic mice. In this secondary analysis, we report that these transgenic mice develop a postnatal corneal neurofibroma with the loss of corneal transparency by age six months. We show that expansion of non-myelinating SCs, under the control of activated ERK1/2, also drive myofibroblast differentiation that derives from both SC precursors and resident corneal keratocytes.

Quantum critical scaling in graphene.

We show that the emergent relativistic symmetry of electrons in graphene near its quantum critical point (QCP) implies a crucial importance of the Coulomb interaction. We derive scaling laws, valid near the QCP, that dictate the nontrivial magnetic and charge response of interacting graphene. Our analysis yields numerous predictions for how the Coulomb interaction will be manifested in experimental observables such as the diamagnetic response and electronic compressibility.

Superfluid transition in a rotating fermi gas with resonant interactions.

We study a rotating atomic Fermi gas near a narrow s-wave Feshbach resonance in a uniaxial trap with frequencies Omega perpendicular, Omega z. We predict the upper-critical angular velocity, omega c2(delta,T), as a function of temperature T and detuning delta across the BEC-BCS crossover. The suppression of superfluidity at omega c2 is distinct in the BCS and BEC regimes, with the former controlled by depairing and the latter by the dilution of bosonic molecules.

BEC-BCS crossover in "magnetized" Feshbach-resonantly paired superfluids.

We map out the detuning-magnetization phase diagram for a magnetized (unequal number of atoms in two pairing hyperfine states) gas of fermionic atoms interacting via an s-wave Feshbach resonance (FR). The phase diagram is dominated by the coexistence of a magnetized normal gas and a singlet-paired superfluid with the latter exhibiting a BCS-Bose Einstein condensate crossover with reduced FR detuning. On the BCS side of strongly overlapping Cooper pairs, a sliver of finite-momentum paired Fulde-Ferrell-Larkin-Ovchinnikov magnetized phase intervenes between the phase-separated and normal states.

Quantum decoupling transition in a one-dimensional Feshbach-resonant superfluid.

We study a one-dimensional gas of fermionic atoms interacting via an s-wave molecular Feshbach resonance. At low energies the system is characterized by two Josephson-coupled Luttinger liquids, corresponding to paired atomic and molecular superfluids. We show that, in contrast to higher dimensions, the system exhibits a quantum phase transition from a phase in which the two superfluids are locked together to one in which, at low energies, quantum fluctuations suppress the Feshbach resonance (Josephson) coupling, effectively decoupling the molecular and atomic superfluids.