Publications by authors named "Daniel Schinor"
Article Synopsis
- Antibody glycosylation plays a crucial role in improving antibody therapeutics, and this study focuses on producing the anti-cancer monoclonal antibody rituximab using the unicellular ciliate Tetrahymena thermophila.
- The produced antibody showed increased efficacy in antibody-dependent cell-mediated cytotoxicity due to unique N-linked glycosylation patterns, including afucosylated and oligomannose-type glycans.
- Analyses suggest that the glycosylation structures in the ciliate closely mimic human glycoproteins and demonstrate potential for large-scale production of monoclonal antibodies with enhanced therapeutic properties.
