Publications by authors named "Daniel Scharfenberg"
Six-month follow-up of multidomain cognitive impairment in non-hospitalized individuals with post-COVID-19 syndrome.
Eur Arch Psychiatry Clin Neurosci
December 2024
Some people infected with SARS-CoV-2 report persisting symptoms following acute infection. If these persist for over three months, they are classified as post-COVID-19 syndrome (PCS). Although PCS is frequently reported, detailed longitudinal neuropsychological characterization remains scarce.
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- Mild cognitive impairment (MCI) is a condition that causes cognitive decline greater than normal age-related changes but does not severely disrupt daily life, and it can be influenced by various factors including neuropsychiatric conditions like depression and anxiety.* -
- The NeuroNation MED Effectiveness Study is a multicenter randomized controlled trial in Germany and Luxembourg, evaluating a 12-week self-administered mobile cognitive training intervention ("NeuroNation MED") for adults with MCI, with a total of 286 participants planned.* -
- Outcomes of the study will focus on cognitive performance improvements and changes in neuropsychiatric symptoms, psychological well-being, and usability of the application, assessing both primary and secondary outcomes before and after the
Background: Isolated REM sleep behavior disorder (iRBD) is an early α-synucleinopathy often accompanied by incipient cognitive impairment. As executive dysfunctions predict earlier phenotypic conversion from iRBD to Parkinson's disease and Lewy body dementia, cognitive training focusing on executive functions could have disease-modifying effects for individuals with iRBD.
Methods: The study CogTrAiL-RBD investigates the short- and long-term effectiveness and the feasibility and underlying neural mechanisms of a cognitive training intervention for individuals with iRBD.
Many patients that were infected with SARS-CoV-2 experience cognitive and affective symptoms weeks and months after their acute COVID-19 disease, even when acute symptoms were mild to moderate. For these patients, purely neurological explanations are struggling to explain the development and maintenance of the great variety of neuropsychiatric and cognitive symptoms occurring after COVID-19. We provide a psychological perspective based on the network theory of mental disorders as an added explanation that does not displace neurological mechanism but rather complements them.
View Article and Find Full Text PDFBackground: A fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part of the post-COVID-19 syndrome. This study aimed to assess the neuropsychological profile of these patients.
Methods: Assessment at baseline (three months or more following acute COVID-19) of a monocentric prospective cohort of patients with post-COVID-19 syndrome.
Background: Social cognition (SC) is a core criterion for neurocognitive disorders. However, findings in patients with amnestic mild cognitive impairment (aMCI) and dementia of the Alzheimer type (DAT) are inconsistent.
Objective: We report assessments of emotion recognition (ER), affective and cognitive theory of mind (ToM) in young (YC) and older controls (OC) compared to aMCI and DAT.