Image-guided helical tomotherapy for localized prostate cancer: technique and initial clinical observations.

The purpose of the present study was to implement a technique for daily computed tomography (CT)-based image-guided radiation therapy and to report observations on treatment planning, imaging, and delivery based on the first 2 years of clinical experience. Patients with previously untreated stage T1-T3 biopsy-proven adenocarcinoma of the prostate were considered eligible for treatment with daily CT-guided helical tomotherapy. The prostate was targeted daily using megavoltage CT (MVCT) images that were fused with treatment-planning CT images based on anatomic alignments.

A model for predicting lung cancer response to therapy.

Purpose: Volumetric computed tomography (CT) images acquired by image-guided radiation therapy (IGRT) systems can be used to measure tumor response over the course of treatment. Predictive adaptive therapy is a novel treatment technique that uses volumetric IGRT data to actively predict the future tumor response to therapy during the first few weeks of IGRT treatment. The goal of this study was to develop and test a model for predicting lung tumor response during IGRT treatment using serial megavoltage CT (MVCT).

A technique for adaptive image-guided helical tomotherapy for lung cancer.

Purpose: The gross tumor volume (GTV) for many lung cancer patients can decrease during the course of radiation therapy. As the tumor reduces in size during treatment, the margin added around the GTV effectively becomes larger, which can result in the excessive irradiation of normal lung tissue. The specific goal of this study is to evaluate the feasibility of using image-guided adaptive radiation therapy to adjust the planning target volume weekly based on the previous week's CT image sets that were used for image-guided patient setup.

Evaluation of image-guided helical tomotherapy for the retreatment of spinal metastasis.

Introduction: Patients with vertebral metastasis that receive radiation therapy are typically treated to the spinal cord tolerance dose. As such, it is difficult to successfully deliver a second course of radiation therapy for patients with overlapping treatment volumes. In this study, an image-guided helical tomotherapy system was evaluated for the retreatment of previously irradiated vertebral metastasis.