Publications by authors named "Daniel Santarsieri"
Numerous clinical trials have been conducted to determine the utility of antidepressant treatment (ADT), psychotherapy, and combined psycho-pharmaco-psychotherapy (PPPT) in treating major depressive disorder (MDD). While all approaches have shown benefit over placebo to varying degrees, the parallel neurophysiological mechanisms that underlie their efficacy have received little attention. The authors will review and discuss a growing body of literature that relates the factors of treatment selection and response to the principles of neuromodulation, with emphasis regarding how neuroimaging and other experimental data reinforce the need for personalized MDD treatment.
View Article and Find Full Text PDFAntidepressant efficacy and side-effect burden: a quick guide for clinicians.
Drugs Context
November 2015
Article Synopsis
- The use of antidepressant treatment (ADT) for major depressive disorder (MDD) has soared in popularity over the last 20 years, attributed to the approval of safer drugs, increased education, and reduced stigma.
- Concerns remain about the safety and effectiveness of ADT, prompting the authors to evaluate the evidence supporting its use through FDA approvals, randomized controlled trials, and theoretical pharmacodynamic principles.
- The paper concludes by comparing common psychopharmacology guidelines with more unconventional practices, providing insight into standard treatment approaches for MDD.