Publications by authors named "Daniel Rossmeisl"
Article Synopsis
- SNAIL is a crucial transcriptional regulator that plays significant roles in embryonic development and cancer, specifically through its influence on epithelial-to-mesenchymal transition (EMT).
- Research indicates that SNAIL has oncogenic functions independent of EMT, exhibiting varied effects depending on the tissue and genetic context, such as either protecting against or promoting tumor growth in different types of cancer.
- The findings reveal that SNAIL's oncogenic effects do not involve typical mechanisms like E-cadherin downregulation, but instead facilitate cancer progression by bypassing cellular senescence and affecting cell cycle regulation through inactivation of the Retinoblastoma (RB) protein.
