Measurement of Urinary Gc-Globulin by a Fluorescence ELISA Technique: Method Validation and Clinical Evaluation in Septic Patients-A Pilot Study.

A major complication of sepsis is the development of acute kidney injury (AKI). In case of acute tubular damage, Gc-globulin, a known serum sepsis marker is increasingly filtrated into the urine therefore, urinary Gc-globulin (u-Gc) levels may predict septic AKI. We developed and validated a competitive fluorescence ELISA method for u-Gc measurement.

Serum Total Antioxidant Capacity (TAC) and TAC/Lymphocyte Ratio as Promising Predictive Markers in COVID-19.

SARS-CoV-2 infection might cause a critical disease, and patients' follow-up is based on multiple parameters. Oxidative stress is one of the key factors in the pathogenesis of COVID-19 suggesting that its level could be a prognostic marker. Therefore, we elucidated the predictive value of the serum non-enzymatic total antioxidant capacity (TAC) and that of the newly introduced TAC/lymphocyte ratio in COVID-19.

Presepsin: gelsolin ratio, as a promising marker of sepsis-related organ dysfunction: a prospective observational study.

Introduction: We aimed to facilitate the diagnosis and prognosis of sepsis-related organ dysfunction through analyzing presepsin (PSEP) and gelsolin (GSN) levels along with a novel marker, the presepsin:gelsolin (PSEP:GSN) ratio.

Methods: Blood samples were collected from septic patients at the intensive care unit (ICU) at three time points (T1-3): T1: within 12 h after admission; T2: second day morning; T3: third day morning. Sampling points for non-septic ICU patients were T1 and T3.

Arrested Friendships? Justice Involvement and Interpersonal Exclusion among Rural Youth.

Objectives: We examine the impacts of adolescent arrest on friendship networks. In particular, we extend labeling theory by testing hypotheses for three potential mechanisms of interpersonal exclusion related to the stigma of arrest: rejection, withdrawal, and homophily.

Method: We use longitudinal data on 48 peer networks from PROSPER, a study of rural youth followed through middle and high school.

Novel Damage Biomarkers of Sepsis-Related Acute Kidney Injury.

Sepsis-related acute kidney injury (AKI) is one of the most common complications of sepsis at the intensive care unit (ICU) with more adverse mortality rates. The early diagnosis and reliable monitoring of sepsis-related AKI are essential in achieving a favorable outcome. Novel serum and urinary biomarkers could yield valuable information during this process.

Similarity of friends versus nonfriends in adolescence: Developmental patterns and ecological influences.

This study examines developmental change across adolescence in the similarity of friends versus nonfriends. This differential in similarity is a key aspect of the organization of the peer context of development: The stronger the correlation between friends for an attribute, the more the attribute delineates clustering and divisions of friendships. We investigated change in the correlation between friends across 12 attributes covering demographics, orientations to key institutions (family, school, religion), and problem behavior, and we expected that the link between similarity and friendship would increase during adolescence for most attributes other than gender.

Urinary actin, as a potential marker of sepsis-related acute kidney injury: A pilot study.

Introduction: A major complication of sepsis is the development of acute kidney injury (AKI). Recently, it was shown that intracellular actin released from damaged tissues appears in the urine of patients with multiple organ dysfunction syndrome. Our aims were to measure urinary actin (u-actin) concentrations of septic and control patients and to test if u-actin levels could predict AKI and mortality.

Moderators of Friend Selection and Influence in Relation to Adolescent Alcohol Use.

Friendships form an important context in which adolescents initiate and establish alcohol use patterns, but not all adolescents may be equally affected by this context. Therefore, this study tests whether parenting practices (i.e.

Social Ties Cut Both Ways: Self-Harm and Adolescent Peer Networks.

Peers play an important role in adolescence, a time when self-harm arises as a major health risk, but little is known about the social networks of adolescents who cut. Peer network positions can affect mental distress related to cutting or provide direct social motivations for self-harm. This study uses PROSPER survey data from U.

New Students' Peer Integration and Exposure to Deviant Peers: Spurious Effects of School Moves?

School moves during adolescence predict lower peer integration and higher exposure to delinquent peers. Yet mobility and peer problems have several common correlates, so differences in movers' and non-movers' social adjustment may be due to selection rather than to causal effects of school moves. Drawing on survey and social network data from a sample of 7th and 8th graders, this study compared the structure and behavioral content of new students' friendship networks to those of not only non-movers, but also of students about to move schools; the latter should resemble new students in both observed and unobserved ways.

WHEN ONSET MEETS DESISTANCE: COGNITIVE TRANSFORMATION AND ADOLESCENT MARIJUANA EXPERIMENTATION.

Purpose: Desistance scholars primarily focus on changing social roles, cognitive transformations, and shifting identities to understand the cessation of serious crime and illicit drug use in adulthood. In the current study, we move the spotlight away from adulthood and toward adolescence, the developmental stage when the prevalence of offending and substance use peak and desistance from most of these behaviors begins. Our primary hypothesis is that changes in perceived psychic rewards surrounding initial forays into marijuana use strongly predict adolescents' decisions to cease or persist that behavior.

Peer beliefs and smoking in adolescence: a longitudinal social network analysis.

Background: Peer smoking is one of the strongest predictors of adolescent cigarette use, but less is known about whether other peer characteristics also contribute to this behavior.

Objectives: This study examined the links between adolescent cigarette use and peer beliefs about smoking. It tested whether peer beliefs about smoking are associated with changes in cigarette use, whether this association is a result of changes in individual beliefs about smoking, and how beliefs inform friendship choices.

Social Networks and the Diffusion of Adolescent Problem Behavior: Reliable Estimates of Selection and Influence from Sixth Through Ninth Grades.

Seeking to reduce problematic peer influence is a prominent theme of programs to prevent adolescent problem behavior. To support the refinement of this aspect of prevention programming, we examined peer influence and selection processes for three problem behaviors (delinquency, alcohol use, and smoking). We assessed not only the overall strengths of these peer processes, but also their consistency versus variability across settings.

Revisiting "What They Think": Adolescent Drinking and the Importance of Peer Beliefs.

The association between delinquent peers and delinquent behavior is among the most consistent findings in the criminological literature, and a number of recent studies have raised the standards for determining the nature and extent of peer influence. Despite these advances, however, key questions about deviant behavior is socially transmitted remain unresolved. In particular, much of the research examining peer influence is limited to peer behavior, despite a rich literature supporting the salience of beliefs, such as expectations and moral approval, in shaping behaviors.

Friends as a Bridge to Parental Influence: Implications for Adolescent Alcohol Use.

The current study investigates the possibility that friendship networks connect adolescents to influence from a broader group of adults beyond their own families. In doing so, we combine two rich traditions of research on adult influence on children and adolescents. Family research has suggested a number of ways in which effective parenting can reduce deviant behavior among adolescents.

Peers and the Emergence of Alcohol Use: Influence and Selection Processes in Adolescent Friendship Networks.

This study addresses not only influence and selection of friends as sources of similarity in alcohol use, but also peer processes leading drinkers to be chosen as friends more often than non-drinkers, which increases the number of adolescents subject to their influence. Analyses apply a stochastic actor-based model to friendship networks assessed five times from 6 through 9 grades for 50 grade cohort networks in Iowa and Pennsylvania, which include 13,214 individuals. Results show definite influence and selection for similarity in alcohol use, as well as reciprocal influences between drinking and frequently being chosen as a friend.

Effects of PROSPER on the influence potential of prosocial versus antisocial youth in adolescent friendship networks.

Objectives: We test the hypothesis that an evidence-based preventive intervention will change adolescent friendship networks to reduce the potential for peer influence toward antisocial behavior. Altering adolescents' friendship networks in this way is a promising avenue for achieving setting-level prevention benefits such as expanding the reach and durability of program effects.

Methods: Beginning in 2002, the Promoting School-University Partnerships to Enhance Resilience (PROSPER) randomized control trial assigned two entire sixth-grade cohorts of 14 rural and small town school districts in Iowa and Pennsylvania to receive the intervention and of 14 to control.