Publications by authors named "Daniel R Rudic"
Article Synopsis
- * The study examined how the timing of a stroke (when it occurs during the day) affects immune activation in mice, noting that certain circadian genes were expressed differently based on the time of day.
- * Findings revealed that strokes occurring during deep sleep (at ZT06) led to higher levels of inflammation and worse physical deficits compared to strokes at other times, suggesting that time of day impacts immune responses and overall stroke consequences.
Stroke is a leading cause of disability and death worldwide. There is evidence that there is a circadian rhythm in stroke with peak occurrence in the morning (6 to 10 am). However, it is not clear if the size of infarcts and the outcome of stroke also varies during the 24-hour period.
View Article and Find Full Text PDFObjective: Perturbation of daily rhythm increases cardiovascular risk. The aim of this study was to determine whether obesity alters circadian gene expression and microvascular function in lean mice and obese (db/db) mice.
Methods: Mice were subjected to normal LD or DD to alter circadian rhythm.