Publications by authors named "Daniel R Peet"
Kinesin-1 is a nanoscale molecular motor that walks towards the fast-growing (plus) ends of microtubules, hauling molecular cargo to specific reaction sites in cells. Kinesin-driven transport is central to the self-organization of eukaryotic cells and shows great promise as a tool for nano-engineering . Recent work hints that kinesin may also play a role in modulating the stability of its microtubule track, both in vitro and in vivo , but the results are conflicting and the mechanisms are unclear.
View Article and Find Full Text PDFArticle Synopsis
- Alp14 is a microtubule polymerase from S. pombe that promotes growth at the plus ends of microtubules, working with Alp7, its binding partner.
- It operates effectively at much lower GTP-tubulin concentrations than typically required, although this increases the risk of microtubule destabilization or "catastrophe."
- Both Alp14 and Alp7 are essential for maintaining microtubule dynamics, and their combined action allows for the creation of stable and rapidly growing microtubules even when tubulin availability is low.