Publications by authors named "Daniel R Fox"
High-resolution cryo-electron microscopy (cryo-EM) requires costly 200- to 300-keV cryo-transmission electron microscopes (cryo-TEMs) with field emission gun (FEG) sources, stable columns, constant-powered lenses, autoloader, and direct electron detectors (DED). Recent advances in 100-keV imaging with the emergence of sub-200-keV optimized DED technology promises the development of more affordable cryo-TEMs. So far, 100-keV imaging has required microscopes with FEG sources.
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- Haemoglobin (Hb) is crucial for transporting oxygen in vertebrates, and its low levels can indicate health issues like anaemia or colon cancer.
- A new sandwich-ELISA test using llama-derived nanobodies (NbE11 and NbB9) has been developed to detect human Hb without reacting to other vertebrates' Hb.
- Researchers have determined the crystal structure of NbE11 paired with human Hb, revealing high affinity binding mainly to the β-Hb subunit, which helps explain the test's specificity for human Hb.