Publications by authors named "Daniel Prior"
DNA damage is fundamental to tumorigenesis, and the inability to repair DNA damage is a hallmark of many human cancers. DNA is repaired via the DNA damage repair (DDR) apparatus, which includes five major pathways. DDR deficiencies in cancers give rise to potential therapeutic targets, as cancers harboring DDR deficiencies become increasingly dependent on alternative DDR pathways for survival.
View Article and Find Full Text PDFNormal Erythroid Precursors in Diamond-Blackfan Anemia: A Rare Case Highlighting Challenges That Remain.
J Pediatr Hematol Oncol
March 2024
Article Synopsis
- Diamond-Blackfan anemia (DBA) is a rare genetic disorder that causes bone marrow failure and can present in different ways among patients.
- Recent advancements in genetic understanding have changed how DBA is diagnosed, with new insights into its various forms.
- The case discussed highlights an unusual patient who experienced spontaneous remission and relapse, raising questions about atypical symptoms and diagnostic challenges in DBA.
Background: Hemolytic disease of the fetus and newborn (HDFN) is characterized by destruction of fetal/neonatal red blood cells (RBCs) secondary to maternally derived antibodies, which are typically thought to be passively acquired via placental transfer. Few cases have examined the possibility of HDFN mediated by maternal antibodies passively transferred via breast milk.
Methods: We describe two cases of persistent HDFN in infants potentially mediated by passively acquired antibodies via maternal breast milk.
Article Synopsis
- The study aimed to understand the preferences of North Wales dentists in interacting with the North Wales Local Dental Committee (NWLDC) through a descriptive cross-sectional survey.
- Out of 167 responses, the majority of dentists preferred communication via email notifications (88%) and virtual meetings (52.1%), while many showed disinterest in attending LDC meetings directly.
- The findings suggest a need for improved communication methods and indicate that an ideal NWLDC website should enhance information accessibility, as many dentists infrequently use the current site.
Article Synopsis
- A survey of North Wales dentists was conducted to evaluate the effectiveness of communication methods used by the North Wales Local Dental Committee (NWLDC) in engaging its members.
- Out of 167 responses, a significant majority of dentists reported receiving insufficient information and very few attended LDC meetings regularly, indicating a disconnect between the committee and its members.
- The findings highlighted a need for improved clarity about the LDC's role and meeting attendance, as current communication strategies are failing to effectively engage the dental community.
Introduction: Enhanced recovery after surgery (ERAS) programs have been successfully implemented in several surgical fields; however, there have been mixed results observed in bariatric surgery. Our institution implemented an enhanced recovery program with specific pre-, intra-, and post-operative protocols aimed at patients, nursing staff, and physicians. The aim of the study is to assess the effectiveness of the ERAS program.
View Article and Find Full Text PDFAll-terrain vehicle (ATV) safety laws, including helmet use, vary by state and are sporadically enforced. Kentucky state laws require safety helmets only for younger riders. We hypothesized that ATV riders injured in Kentucky and seen at a Tennessee trauma center would more likely be unhelmeted, have more severe head injuries, and have higher mortality rates than those injured in Virginia or Tennessee.
View Article and Find Full Text PDFObjectives: Motorcycle helmet laws vary by state, with Kentucky requiring helmets only for younger riders. We hypothesized that motorcyclists injured in Kentucky and seen at a Tennessee trauma center would be more likely to be unhelmeted, have more severe head injuries, and sustain more fatal injuries than those injured in Tennessee or Virginia.
Methods: A Trauma Registry review of 729 injured motorcyclists from January 2005 through June 2015 examined state location of crash, demographics, helmet use, and clinical outcomes.
Formalin is a known carcinogen, so there is a need to establish whether a safer alternative is available for the sterilization of human teeth destined for use in clinical training. Any disinfectant that is not capable of sterilizing 100 percent of the samples tested should be considered a failure. In this study, biofilms of oral bacteria were grown on previously autoclaved extracted human teeth.
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