Publications by authors named "Daniel Plaksin"
Article Synopsis
- Polymer-based formulations, specifically combining hyaluronic acid and polyvinylpyrrolidone, are explored for improved intraarticular drug delivery, particularly to prevent early leakage of adalimumab from the joint.
- The study finds that these polymers exhibit beneficial rheological properties, allowing them to restore the characteristics of synovial fluid and reduce the permeation of adalimumab through synovial membranes significantly.
- Additionally, the research reveals that adalimumab retention is influenced by electrostatic interactions with hyaluronic acid, highlighting the potential for these combinations to enhance both drug retention and joint lubrication.
Recombinant FSH proteins are important therapeutic agents for the treatment of infertility, including follitropin alfa expressed in Chinese Hamster Ovary (CHO) cells and, more recently, follitropin delta expressed in the human cell line PER.C6. These recombinant FSH proteins have distinct glycosylation, and have distinct pharmacokinetic and pharmacodynamic profiles in women.
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