Publications by authors named "Daniel Philip Gale"
Article Synopsis
- Membranous nephropathy (MN) is the main cause of nephrotic syndrome in adults, distinguished by autoantibodies against specific glomerular antigens like PLA2R1 and THSD7A.
- Researchers genotyped 1,409 MN patients to compare genetic risk factors associated with different autoantibody statuses against a control group.
- The findings show that patients with anti-PLA2R1 antibodies have a higher genetic risk score (GRS) compared to controls and those with anti-THSD7A antibodies, indicating distinct genetic influences and suggesting some antibody-negative MN cases might still be linked to autoimmunity against PLA2R1.
Background: Collagen IV-related nephropathies, including thin basement membrane nephropathy and Alport Syndrome (AS), are caused by defects in the genes COL4A3, COL4A4 and COL4A5. Diagnosis of these conditions can be hindered by variable penetrance and the presence of non-specific clinical or pathological features.
Methods: Three families with unexplained inherited kidney disease were recruited from Shanghai, China.