Carnosinase inhibition enhances reactive species scavenging in high fat diet.

Aims: Life expectancy is typically reduced by 2-4 years in people with a body mass index (BMI) of 30-35 kg/m and by 8-10 years in people with a BMI of 40-50 kg/m. Obesity is also associated with onset, or exacerbation of, multiple chronic diseases. Mechanistically, this, in part, involves formation of advanced glycation and lipidation end-products that directly bond with proteins, lipids, or DNA, thereby perturbing typical cellular function.