Crystal engineering of a new platform of hybrid ultramicroporous materials and their CH/CO separation properties.

Hybrid ultramicroporous materials (HUMs) comprised of combinations of organic and inorganic linker ligands are a leading class of physisorbents for trace separations involving C1, C2 and C3 gases. First generation HUMs are modular in nature since they can be self-assembled from transition metal cations, ditopic linkers and inorganic "pillars", as exemplified by the prototypal variant, SIFSIX-3-Zn (3 = pyrazine, SIFSIX = SiF ). Conversely, HUMs that utilise chelating ligands such as ethylenediamine derivatives are yet to be explored as sorbents.

Pillar Modularity in Topology Hybrid Ultramicroporous Materials Based upon Tetra(4-pyridyl)benzene.

Hybrid ultramicroporous materials (HUMs) are porous coordination networks composed of combinations of organic and inorganic linker ligands with a pore diameter of <7 Å. Despite their benchmark gas sorption selectivity for several industrially relevant gas separations and their inherent modularity, the structural and compositional diversity of HUMs remains underexplored. In this contribution, we report a family of six HUMs (, , , , , and ) based on Zn metal centers and the tetratopic N-donor organic ligand tetra(4-pyridyl)benzene ().

Flexible Coordination Network Exhibiting Water Vapor-Induced Reversible Switching between Closed and Open Phases.

That physisorbents can reduce the energy footprint of water vapor capture and release has attracted interest because of potential applications such as moisture harvesting, dehumidification, and heat pumps. In this context, sorbents exhibiting an S-shaped single-step water sorption isotherm are desirable, most of which are structurally rigid sorbents that undergo pore-filling at low relative humidity (RH), ideally below 30% RH. Here, we report that a new flexible one-dimensional (1D) coordination network, [Cu(HQS)(TMBP)] (HHQS = 8-hydroxyquinoline-5-sulfonic acid and TMBP = 4,4'-trimethylenedipyridine), exhibits at least five phases: two as-synthesized open phases, α ⊃ HO and β ⊃ MeOH; an activated closed phase (γ); CO (δ ⊃ CO) and CH (ϵ ⊃ CH) loaded phases.

The First Sulfate-Pillared Hybrid Ultramicroporous Material, SOFOUR-1-Zn, and Its Acetylene Capture Properties.

Hybrid ultramicroporous materials, HUMs, are comprised of metal cations linked by combinations of inorganic and organic ligands. Their modular nature makes them amenable to crystal engineering studies, which have thus far afforded four HUM platforms (as classified by the inorganic linkers). HUMs are of practical interest because of their benchmark gas separation performance for several industrial gas mixtures.

Associations of sleep duration and sleep-wake rhythm with lung parenchymal abnormalities on computed tomography: The MESA study.

Impairment of the circadian rhythm promotes lung inflammation and fibrosis in pre-clinical models. We aimed to examine whether short and/or long sleep duration and other markers of sleep-wake patterns are associated with a greater burden of lung parenchymal abnormalities on computed tomography among adults. We cross-sectionally examined associations of sleep duration captured by actigraphy with interstitial lung abnormalities (n = 1111) and high attenuation areas (n = 1416) on computed tomography scan in the Multi-Ethnic Study of Atherosclerosis at Exam 5 (2010-2013).

The "Chemistree" of Porous Coordination Networks: Taxonomic Classification of Porous Solids to Guide Crystal Engineering Studies.

New approaches to gas/vapor storage and purification are urgently needed to address the large energy footprint, cost, and/or risk associated with existing technologies. In this context, new classes of porous physisorbents, exemplified by porous coordination networks (PCNs), have emerged. There are now >100 000 entries in the Cambridge Structural Database (CSD) metal-organic framework (MOF) subset and the rate of publication, >5000 per year, grows unabatedly.

Agreement of sleep specialists with registered nurses' sleep study orders in supervised clinical practice.

Study Objectives: Incorporating registered nurses (RN-level) into obstructive sleep apnea (OSA) management decisions has the potential to augment the workforce and improve patient access, but the appropriateness of such task-shifting in typical practice is unclear.

Methods: Our medical center piloted a nurse triage program for sleep medicine referrals. Using a sleep specialist-designed decision-making tool, nurses triaged patients referred for initial sleep studies to either home sleep apnea test (HSAT) or in-laboratory polysomnography (PSG).

[Cu(4-phenylpyridine)(trifluoromethanesulfonate)], a Werner complex that exhibits high selectivity for o-xylene.

[Cu(4-phenylpyridine)4(trifluoromethanesulfonate)2] is a new Werner complex that exhibits switching behaviour between non-porous (apohost) and porous (guest-loaded) phases upon exposure to o-xylene but not when exposed to other C8 isomers. High o-xylene selectivity (>6) vs. the other C8 isomers was observed from binary mixtures, only the third occurrence across all sorbent types.

Introduction to Obstructive Sleep Apnea for the Internist.

Introduction: The prevalence of sleep-disordered breathing is increasing, and there are insufficient sleep medicine specialists to meet the clinical demand of caring for these patients. One way to meet this clinical need is to train primary care and internal medicine physicians to provide some of the care. However, trainees in these specialties often receive very little training on practical aspects of the management of obstructive sleep apnea (OSA).

Risk of Cardiovascular Disease Related to Smoking Is Greater Among Women With Sleep-Disordered Breathing.

Study Objectives: Although both sleep-disordered breathing (SDB) and smoking are associated with cardiovascular disease (CVD), the potential for an interactive effect on CVD risk has not been explored. Our objective was to determine if smoking-related risk for CVD rises with greater SDB severity.

Methods: Polysomnography and smoking history were obtained in 3,852 men and women in the Sleep Heart Health Study without baseline CVD.

Consumer Sleep Technology: An American Academy of Sleep Medicine Position Statement.

Consumer sleep technologies (CSTs) are widespread applications and devices that purport to measure and even improve sleep. Sleep clinicians may frequently encounter CST in practice and, despite lack of validation against gold standard polysomnography, familiarity with these devices has become a patient expectation. This American Academy of Sleep Medicine position statement details the disadvantages and potential benefits of CSTs and provides guidance when approaching patient-generated health data from CSTs in a clinical setting.

Habitual Sleep Duration and All-Cause Mortality in a General Community Sample.

Study Objectives: The current study sought to determine whether sleep duration and change in sleep duration are associated with all-cause mortality in a community sample of middle-aged and older adults while accounting for several confounding factors including prevalent sleep-disordered breathing (SDB).

Methods: Habitual sleep duration was assessed using self-report (< 7, 7-8, ≥ 9 h/night) at the baseline and at the follow-up visits of the Sleep Heart Health Study. Techniques of survival analysis were used to relate habitual sleep duration and change in sleep duration to all-cause mortality after adjusting for covariates such as age, sex, race, body mass index, smoking history, prevalent hypertension, diabetes, cardiovascular disease, antidepressant medication use, and SDB severity.

Associations between prescription opioid use and sleep impairment among veterans with chronic pain.

Objective: Chronic pain is associated with impairments in sleep; however, the relationship between prescription opioid status and sleep is unclear. The primary aim of this study was to examine differences in self-reported sleep quality between groups of patients who varied based on chronic pain and prescription opioid status.

Design: This is a cross-sectional study with retrospective review of patient medical records.

Resistant hypertension and obstructive sleep apnea.

Hypertension (HTN) is a modifiable, highly prevalent risk factor for cardiovascular morbidity and renal dysfunction worldwide. In the United States, HTN affects one in three adults, contributes to one out of every seven deaths and to nearly half of all cardiovascular disease-related deaths. HTN is considered resistant when the blood pressure remains above goal despite lifestyle modification and administration of three antihypertensive agents of different classes including a diuretic.

Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in Osteoporotic Fractures in Men (MrOS) Sleep Study.

Study Objectives: Assess the association between REM predominant obstructive sleep apnea (OSA), sleepiness, and quality of life in a community-based cohort of men ≥ 65 years-old. DESIGN INTERVENTION AND MEASUREMENTS: A cross-sectional analysis of 2,765 subjects from the Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study was performed to identify subjects with an apnea hypopnea index (AHI) < 15 (n = 2,044). Subjects were divided into groups based on the AHI in REM sleep (< 5 [referent group], 5 to < 15, 15 to < 30, and ≥ 30).

Lower extremity edema and pulmonary hypertension in morbidly obese patients with obstructive sleep apnea.

Introduction: In 70 consecutive male patients with obstructive sleep apnea (OSA) diagnosed at the Northport VA Medical Center Sleep Disorders Center, we have characterized the association between obesity, OSA, and pulmonary hypertension (PH).

Materials And Methods: By including anthropometric, pulmonary function, and sleep study parameters in a multivariate logistic regression model, we found that a BMI of >40 kg/m(2) and the minimum oxygen saturation in non-rapid eye movement (NREM) sleep predicted the presence of pretibial edema in this sleep apnea population. We then characterized the hemodynamics of those OSA patients that had lower extremity edema.

Exhaled nasal nitric oxide output is reduced in humans at night during the sleep period.

The physiologic function of nasal nitric oxide (NO) release is unknown. In prior experiments, topical NG-nitro-L-arginine methyl ester (L-NAME) on nasal mucosa reduced exhaled nasal NO output and caused daytime sleepiness. We hypothesized that nasal NO output is reduced at night during the sleep period.

Upper airway response to electrical stimulation of the genioglossus in obstructive sleep apnea.

Contraction of the genioglossus (GG) has been shown to improve upper airway patency. In the present study, we evaluated responses in upper airway pressure-flow relationships during sleep to electrical stimulation (ES) of the GG in patients with obstructive sleep apnea. Five patients with chronically implanted hypoglossal nerve (HG) electrodes and nine patients with fine-wire electrodes inserted into the GG were studied.

The symptoms and signs of upper airway resistance syndrome: a link to the functional somatic syndromes.

Study Objectives: The functional somatic syndromes are associated with a variety of symptoms/signs of uncertain etiology. We determined the prevalence of several of those symptoms/signs in patients with sleep-disordered breathing and examined the relationship between the prevalence of the symptoms/signs and the severity of sleep-disordered breathing.

Design: A descriptive study without intervention.