Publications by authors named "Daniel Nouri-Nejad"
Melanoma is the most aggressive skin malignancy with increasing incidence worldwide. Pannexin1 (PANX1), a member of the pannexin family of channel-forming glycoproteins, regulates cellular processes in melanoma cells including proliferation, migration, and invasion/metastasis. However, the mechanisms responsible for coordinating and regulating PANX1 function remain unclear.
View Article and Find Full Text PDFPannexin 1 (PANX1) is a glycoprotein that forms large pore channels capable of passing ions and metabolites such as ATP for cellular communication. PANX1 has been implicated in many diseases including breast cancer and melanoma, where inhibition or deletion of PANX1 reduced the tumorigenic and metastatic properties of the cancer cells. We interrogated the effect of single amino acid changes in various PANX1 domains using naturally occurring variants reported in cancer patient tumors.
View Article and Find Full Text PDFArticle Synopsis
- Pannexin 1 (PANX1) is a glycoprotein found in various tissues, including skin, and forms channels that let ions and small molecules like ATP pass through.
- The study reveals that PANX1 is frequently expressed in human melanoma tumors and reducing its levels or blocking its function leads to decreased cell growth and increased melanin production in melanoma cell lines.
- PANX1 appears to influence tumor growth and progression by affecting signaling pathways, particularly the Wnt/β-catenin pathway, highlighting its potential as a target for melanoma treatment.