Auto-Rejection of Renal Donor-Origin Metastatic Melanoma.

We report a case of metastatic malignant melanoma discovered in a living related donor shortly after renal transplant and subsequently diagnosed in the recipient. The recipient hepatic metastases were followed with serial computed tomography (CT) during regression/rejection of tumor after cessation of immunosuppression and allograft removal. Correlation made with serial liver mass biopsies.

Acute rapamycin nephrotoxicity in native kidneys of patients with chronic glomerulopathies.

Background: Based on its success as a transplant immunosuppressor, there is intense interest in using rapamycin in the treatment of progressive glomerulopathies involving native kidneys. However, we call attention to the potential toxicity associated with the use of rapamycin in this setting.

Methods: We conducted a study to examine the efficacy and safety of rapamycin in patients with progressive chronic renal failure.